Document Detail


Coordinating electrical activity of the heart: ankyrin polypeptides in human cardiac disease.
MedLine Citation:
PMID:  21457127     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Over the past ten years, ankyrin polypeptides have emerged as players in cardiac excitation-contraction coupling. Once thought to solely play a structural role, loss-of-function variants of genes encoding ankyrin polypeptides have highlighted how this protein mediates subcellular localization of various electrical components of the excitation-contraction coupling machinery. Evidence has revealed how disruption of this localization is the primary cause of various cardiomyopathies, ranging from long-QT syndrome 4, to sinus node disease, to more common forms of arrhythmias.
AREAS COVERED: The roles of ankyrin polypeptides in excitation-contraction coupling in the heart and the development of ankyrin-specific cardiomyopathies. How ankyrin polypeptides may be involved in structural and electrical remodeling of the heart, post-myocardial infarct. How ankyrin interactions with membrane-bound ion channels may regulate these channels' response to stimuli. New data, which offers the potential for unique therapies, for not only combating heart disease, but also for wider applications to various disease states.
EXPERT OPINION: The ankyrin family of adapter proteins is emerging as an intimate player in cardiac excitation-contraction coupling. Until recently, these proteins have gone largely unappreciated for their importance in proper cardiac function. New insights into how these proteins function within the heart are offering potentially new avenues for therapies against cardiomyopathy.
Authors:
Jerry Curran; Peter J Mohler
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2011-04-04
Journal Detail:
Title:  Expert opinion on therapeutic targets     Volume:  15     ISSN:  1744-7631     ISO Abbreviation:  Expert Opin. Ther. Targets     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-06-09     Completed Date:  2011-09-30     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  101127833     Medline TA:  Expert Opin Ther Targets     Country:  England    
Other Details:
Languages:  eng     Pagination:  789-801     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Ankyrins / genetics,  metabolism*
Heart / physiopathology*
Heart Diseases / metabolism,  physiopathology*
Humans
Grant Support
ID/Acronym/Agency:
F32 HL114252/HL/NHLBI NIH HHS; HLO8 3422//PHS HHS; HLO8 4583//PHS HHS; R01 HL083422/HL/NHLBI NIH HHS; R01 HL083422-08/HL/NHLBI NIH HHS; R01 HL084583/HL/NHLBI NIH HHS; R01 HL084583-06/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ankyrins
Comments/Corrections

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