Document Detail


Coordinated reset has sustained aftereffects in Parkinsonian monkeys.
MedLine Citation:
PMID:  23280797     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816-820.
Authors:
Peter A Tass; Li Qin; Christian Hauptmann; Sandra Dovero; Erwan Bezard; Thomas Boraud; Wassilios G Meissner
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  72     ISSN:  1531-8249     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2013-01-02     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  816-20     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Neurological Association.
Affiliation:
Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany; Division for Neuromodulation, Medical School, University of Cologne, Cologne, Germany.
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