| Coordinated reset has sustained aftereffects in Parkinsonian monkeys. | |
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MedLine Citation:
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PMID: 23280797 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816-820. |
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Authors:
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Peter A Tass; Li Qin; Christian Hauptmann; Sandra Dovero; Erwan Bezard; Thomas Boraud; Wassilios G Meissner |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of neurology Volume: 72 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 816-20 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 American Neurological Association. |
Affiliation:
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Institute for Medicine and Neurosciences, Research Center Jülich, Jülich, Germany; Division for Neuromodulation, Medical School, University of Cologne, Cologne, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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