| Coordinated morphogenesis of epithelia during development of the Caenorhabditis elegans uterine-vulval connection. | |
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MedLine Citation:
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PMID: 8790329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Development of the nematode egg-laying system requires the formation of a connection between the uterine lumen and the developing vulval lumen, thus allowing a passage for eggs and sperm. This relatively simple process serves as a model for certain aspects of organogenesis. Such a connection demands that cells in both tissues become specialized to participate in the connection, and that the specialized cells are brought in register. A single cell, the anchor cell, acts to induce and to organize specialization of the epidermal and uterine epithelia, and registrates these tissues. The inductions act via evolutionarily conserved intercellular signaling pathways. The anchor cell induces the vulva from ventral epithelial cells via the LIN-3 growth factor and LET-23 transmembrane tyrosine kinase. It then induces surrounding uterine intermediate precursors via the receptor LIN-12, a founding member of the Notch family of receptors. Both signaling pathways are used multiple times during development of Caenorhabditis elegans. The outcome of the signaling is context-dependent. Both inductions are reciprocated. After the anchor cell has induced the vulva, it stretches toward the induced vulval cells. After the anchor cell has induced specialized uterine intermediate precursor cells, it fuses with a subset of their progeny. |
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Authors:
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A P Newman; P W Sternberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 93 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1996 Sep |
Date Detail:
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Created Date: 1996-10-24 Completed Date: 1996-10-24 Revised Date: 2012-06-01 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9329-33 Citation Subset: IM |
Affiliation:
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Howard Hughes Medical Institute, Division of Biology, Pasadena, CA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Caenorhabditis elegans / embryology, genetics* Caenorhabditis elegans Proteins* Cell Communication Cell Differentiation Cell Fusion Epidermal Growth Factor / metabolism Epithelium / embryology Female Gene Expression Regulation, Developmental* Helminth Proteins / metabolism Morphogenesis / genetics Receptor, Epidermal Growth Factor / metabolism Uterus / embryology* Vulva / embryology* |
| Chemical | |
Reg. No./Substance:
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0/Caenorhabditis elegans Proteins; 0/Helminth Proteins; 148412-70-8/Lin-3 protein, C elegans; 62229-50-9/Epidermal Growth Factor; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/let-23 protein, C elegans |
| Comments/Corrections | |
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