Document Detail


Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
MedLine Citation:
PMID:  12065578     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
IN CONCLUSION: MCD, GPAT, and ACC are coordinately regulated by AMPK in liver and adipose tissue in response to exercise, and except for GPAT, also in muscle. The results suggest that AMPK activation plays a major role in regulating lipid metabolism in many cells following exercise. They also suggest that in each of them, it acts to increase fatty acid oxidation and decrease its esterification.
Authors:
Haejoe Park; Virendar K Kaushik; Scarlet Constant; Marc Prentki; Ewa Przybytkowski; Neil B Ruderman; Asish K Saha
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2002-06-13
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  277     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-02     Completed Date:  2002-10-29     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  32571-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
AMP-Activated Protein Kinases
Acetyl-CoA Carboxylase / metabolism*
Adipose Tissue / enzymology,  metabolism
Animals
Carboxy-Lyases / metabolism*
Gene Expression Regulation, Enzymologic
Glycerol-3-Phosphate O-Acyltransferase / metabolism*
Lipid Metabolism
Liver / enzymology
Male
Models, Biological
Multienzyme Complexes / metabolism*
Muscle, Skeletal / enzymology*
Phosphorylation
Physical Conditioning, Animal*
Precipitin Tests
Protein-Serine-Threonine Kinases / metabolism*
Rats
Rats, Sprague-Dawley
Spectrophotometry
Time Factors
Tissue Distribution
Grant Support
ID/Acronym/Agency:
DK 49147/DK/NIDDK NIH HHS; DK19514/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Multienzyme Complexes; EC 2.3.1.15/Glycerol-3-Phosphate O-Acyltransferase; EC 2.7.11.1/AMP-Activated Protein Kinases; EC 2.7.11.1/Protein-Serine-Threonine Kinases; EC 4.1.1.-/Carboxy-Lyases; EC 4.1.1.9/malonyl-CoA decarboxylase; EC 6.4.1.2/Acetyl-CoA Carboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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