Document Detail

Coordinate regulation of gallbladder motor function in the gut-liver axis.
MedLine Citation:
PMID:  18506897     Owner:  NLM     Status:  MEDLINE    
Gallstones are one of the most common digestive diseases with an estimated prevalence of 10%-15% in adults living in the western world, where cholesterol-enriched gallstones represent 75%-80% of all gallstones. In cholesterol gallstone disease, the gallbladder becomes the target organ of a complex metabolic disease. Indeed, a fine coordinated hepatobiliary and gastrointestinal function, including gallbladder motility in the fasting and postprandial state, is of crucial importance to prevent crystallization and precipitation of excess cholesterol in gallbladder bile. Also, gallbladder itself plays a physiopathological role in biliary lipid absorption. Here, we present a comprehensive view on the regulation of gallbladder motor function by focusing on recent discoveries in animal and human studies, and we discuss the role of the gallbladder in the pathogenesis of gallstone formation.
Piero Portincasa; Agostino Di Ciaula; Helen H Wang; Giuseppe Palasciano; Karel J van Erpecum; Antonio Moschetta; David Q-H Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  47     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2112-26     Citation Subset:  IM    
Department of Internal Medicine and Public Medicine, Clinica Medica A. Murri, University of Bari Medical School, Bari, Italy.
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MeSH Terms
Bile / physiology
Gallbladder / physiology*,  physiopathology
Gallstones / etiology,  physiopathology
Gastrointestinal Motility / physiology
Gastrointestinal Tract / physiology*
Liver / physiology*
Grant Support

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