Document Detail

Cooperative Hydrogen-Bond Pairing in Organocatalytic Ring-Opening Polymerization.
MedLine Citation:
PMID:  25400295     Owner:  NLM     Status:  Publisher    
Thiourea (TU)/amine base cocatalysts are commonly employed for well-controlled, highly active "living" organocatalytic ring-opening polymerizations (ROPs) of cyclic esters and carbonates. In this work, several of the most active cocatalyst pairs are shown by (1)H NMR binding studies to be highly associated in solution, dominating all other known noncovalent catalyst/reagent interactions during ROP. One strongly binding catalyst pair behaves kinetically as a unimolecular catalyst species. The high selectivity and activity exhibited by these ROP organocatalysts are attributed to the strong binding between the two cocatalysts, and the predictive utility of these binding parameters is applied for the discovery of a new, highly active cocatalyst pair.
Oleg I Kazakov; Partha P Datta; Meghedi Isajani; Elizabeth T Kiesewetter; Matthew K Kiesewetter
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-10-22
Journal Detail:
Title:  Macromolecules     Volume:  47     ISSN:  0024-9297     ISO Abbreviation:  Macromolecules     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-17     Completed Date:  -     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  0365316     Medline TA:  Macromolecules     Country:  -    
Other Details:
Languages:  ENG     Pagination:  7463-7468     Citation Subset:  -    
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