Document Detail


Convulsant and anticonvulsant effects of bupropion in mice.
MedLine Citation:
PMID:  15363958     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study demonstrated that bupropion hydrochloride, an effective antidepressant and a commonly used smoking cessation aid, dose-dependently caused clonic convulsions in mice, with the CD50 (convulsive dose50, i.e., the dose producing convulsions in 50% of mice) at 119.7 mg kg(-1). An evaluation for anticonvulsant effects showed that bupropion in the doses of 15-30 mg kg(-1) protected against convulsions induced by maximal electroshock with the ED50 (effective dose50, i.e., the dose protected 50% of mice against convulsions) being 19.4 mg kg(-1). Bupropion had no effect on pentylenetetrazole- and kainic acid-induced convulsions. It is possible that the anticonvulsant activity of bupropion may be exploited for use in the treatment of epilepsy but it requires further investigations.
Authors:
Piotr Tutka; Bartlomiej Barczynski; Marian Wielosz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  499     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-09-14     Completed Date:  2005-02-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  117-20     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Medical University of Lublin, Jaczewskiego 8, PL-20-090 Lublin, Poland. tutka@eskulap.am.lublin.pl
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology*
Bupropion / pharmacology*
Convulsants / pharmacology*
Dose-Response Relationship, Drug
Electroshock / adverse effects
Kainic Acid / toxicity
Male
Mice
Pentylenetetrazole / toxicity
Seizures / etiology,  mortality,  prevention & control*
Survival Rate
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Convulsants; 34841-39-9/Bupropion; 487-79-6/Kainic Acid; 54-95-5/Pentylenetetrazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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