| Converting enzyme inhibitors regressed cardiac hypertrophy and reduced tissue angiotensin II in spontaneously hypertensive rats. | |
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MedLine Citation:
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PMID: 1653794 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the role of the tissue renin-angiotensin system in left ventricular hypertrophy, converting enzyme inhibitors were administered orally to 12-week-old male spontaneously hypertensive rats (SHR) for 4 weeks, and cardiac tissue angiotensin II was measured. Treatment with enalapril (10 mg/kg per day) and trandolapril (1 mg/kg per day) lowered systolic blood pressure, left ventricular weight and left ventricular angiotensin II content. Plasma angiotensin II concentration was increased by the treatment with enalapril whereas trandolapril did not cause any change. There was significantly positive correlation between left ventricular weight and angiotensin II content. Because angiotensin II promotes cell proliferation, these results suggest that cardiac tissue angiotensin II, rather than circulating angiotensin II, may account for the pathophysiology of left ventricular hypertrophy in SHR. |
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Authors:
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M Nagano; J Higaki; H Mikami; M Nakamaru; K Higashimori; K Katahira; Y Tabuchi; A Moriguchi; F Nakamura; T Ogihara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of hypertension Volume: 9 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 1991 Jul |
Date Detail:
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Created Date: 1991-10-17 Completed Date: 1991-10-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 595-9 Citation Subset: IM |
Affiliation:
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Department of Geriatric Medicine, Osaka University Medical School, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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metabolism* Angiotensin-Converting Enzyme Inhibitors / pharmacology* Animals Blood Pressure / drug effects Cardiomegaly / drug therapy*, physiopathology Enalapril / pharmacology* Heart Atria / pathology Heart Ventricles / pathology Indoles / pharmacology* Male Myocardium / metabolism, pathology Organ Size / drug effects Rats Rats, Inbred SHR Renin-Angiotensin System / drug effects, physiology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Indoles; 11128-99-7/Angiotensin II; 75847-73-3/Enalapril; 87679-37-6/trandolapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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