Document Detail


Converting enzyme inhibition improves congestion and survival in hypertensive rats with high-output heart failure.
MedLine Citation:
PMID:  7511728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of angiotensin-converting enzyme (ACE) inhibitors in high-output heart failure have not yet been well established. We evaluated the effects of lisinopril (3 mg/kg/day) on hemodynamics, neurohormones, and survival in 10-week-old spontaneously hypertensive rats (SHR) with aortocaval fistula. Sham-operated treated and untreated SHR served as controls. Cardiac output (CO) was determined by thermodilution method, and renal blood flow (RBF) was assessed by laser-Doppler flowmetry. In sham-operated SHR, 2-week treatment with lisinopril decreased blood pressure (BP), left ventricular (LV) weight, and total peripheral resistance (TPR) (p < 0.01 each) and increased RBF and plasma renin activity (PRA) (both p < 0.05); CO and LV end-diastolic pressure (LVEDP) were unchanged. Fistula creation induced biventricular hypertrophy and high-output heart failure [increased LVEDP, CO, pulse pressure, and plasma norepinephrine (NE) and decreased RBF] with congestive signs (ascites, tachypnea). Lisinopril decreased LVEDP (p < 0.01), increased RBF, prolonged survival (both p < 0.05), and prevented ascites (0 vs. 46%) and increased PRA (p < 0.05) and attenuated the increase in plasma NE. Heart weight, BP, and CO were not affected by lisinopril. Thus, lisinopril ameliorated congestion and improved survival in SHR with fistula without compromising cardiorenal hemodynamics. Venous and renal dilatation and attenuation of vasoconstrictive systems may have contributed to the beneficial effects.
Authors:
H Nishimura; T Oka; M Ueyama; J Kubota; K Kawamura
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  23     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-05-02     Completed Date:  1994-05-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Osaka Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Cardiomegaly / drug therapy
Heart / drug effects
Heart Failure / drug therapy*,  mortality
Heart Ventricles / drug effects
Hemodynamics / drug effects*
Hypertension / drug therapy*,  physiopathology
Kidney / drug effects
Lisinopril / pharmacology,  therapeutic use*
Male
Organ Size / drug effects
Rats
Rats, Inbred SHR
Renal Circulation / drug effects
Vascular Resistance / drug effects
Vasodilation / drug effects
Chemical
Reg. No./Substance:
83915-83-7/Lisinopril

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