Document Detail

Converted neural cells: induced to a cure?
MedLine Citation:
PMID:  22410787     Owner:  NLM     Status:  MEDLINE    
Many neurodegenerative disorders such as Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and others often occur as a result of progressive loss of structure or function of neurons. Recently, many groups were able to generate neural cells, either differentiated from induced pluripotent stem cells (iPSCs) or converted from somatic cells. Advances in converted neural cells have opened a new era to ease applications for modeling diseases and screening drugs. In addition, the converted neural cells also hold the promise for cell replacement therapy (Kikuchi et al., 2011; Krencik et al., 2011; Kriks et al., 2011; Nori et al., 2011; Rhee et al., 2011; Schwartz et al., 2012). Here we will mainly discuss most recent progress on using converted functional neural cells to treat neurological diseases and highlight potential clinical challenges and future perspectives.
Weiqi Zhang; Shunlei Duan; Ying Li; Xiuling Xu; Jing Qu; Weizhou Zhang; Guang-Hui Liu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-11
Journal Detail:
Title:  Protein & cell     Volume:  3     ISSN:  1674-8018     ISO Abbreviation:  Protein Cell     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-03-19     Completed Date:  2012-06-25     Revised Date:  2014-08-13    
Medline Journal Info:
Nlm Unique ID:  101532368     Medline TA:  Protein Cell     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
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MeSH Terms
Amyotrophic Lateral Sclerosis / therapy
Cell Transdifferentiation
Cell- and Tissue-Based Therapy
Induced Pluripotent Stem Cells / cytology
Neurons / cytology*,  transplantation
Parkinson Disease / therapy
Stroke / therapy
Grant Support

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