Document Detail


Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.
MedLine Citation:
PMID:  12351789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Unc104/KIF1A belongs to a class of monomeric kinesin motors that have been thought to possess an unusual motility mechanism. Unlike the unidirectional motion driven by the coordinated actions of the two heads in conventional kinesins, single-headed KIF1A was reported to undergo biased diffusional motion along microtubules. Here, we show that Unc104/KIF1A can dimerize and move unidirectionally and processively with rapid velocities characteristic of transport in living cells. These results suggest that Unc104/KIF1A operates in vivo by a mechanism similar to conventional kinesin and that regulation of motor dimerization may be used to control transport by this class of kinesins.
Authors:
Michio Tomishige; Dieter R Klopfenstein; Ronald D Vale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  297     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2263-7     Citation Subset:  IM    
Affiliation:
The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins / chemistry,  physiology
Diffusion
Dimerization
Humans
Kinesin / chemistry*,  physiology
Liposomes
Microtubules / physiology*
Molecular Motor Proteins / chemistry*,  physiology*
Molecular Sequence Data
Movement
Mutation
Nerve Tissue Proteins / chemistry*,  physiology*
Protein Structure, Tertiary
Rats
Recombinant Fusion Proteins / chemistry
Grant Support
ID/Acronym/Agency:
AR42895/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/KIF1A protein, human; 0/Kif1a protein, rat; 0/Liposomes; 0/Molecular Motor Proteins; 0/Nerve Tissue Proteins; 0/Recombinant Fusion Proteins; 0/UNC-104 protein, C elegans; EC 3.6.1.-/Kinesin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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