Document Detail

Conversion of Unc104/KIF1A kinesin into a processive motor after dimerization.
MedLine Citation:
PMID:  12351789     Owner:  NLM     Status:  MEDLINE    
Unc104/KIF1A belongs to a class of monomeric kinesin motors that have been thought to possess an unusual motility mechanism. Unlike the unidirectional motion driven by the coordinated actions of the two heads in conventional kinesins, single-headed KIF1A was reported to undergo biased diffusional motion along microtubules. Here, we show that Unc104/KIF1A can dimerize and move unidirectionally and processively with rapid velocities characteristic of transport in living cells. These results suggest that Unc104/KIF1A operates in vivo by a mechanism similar to conventional kinesin and that regulation of motor dimerization may be used to control transport by this class of kinesins.
Michio Tomishige; Dieter R Klopfenstein; Ronald D Vale
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  297     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-27     Completed Date:  2002-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2263-7     Citation Subset:  IM    
The Howard Hughes Medical Institute and the Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94143, USA.
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MeSH Terms
Amino Acid Sequence
Caenorhabditis elegans
Caenorhabditis elegans Proteins / chemistry,  physiology
Kinesin / chemistry*,  physiology
Microtubules / physiology*
Molecular Motor Proteins / chemistry*,  physiology*
Molecular Sequence Data
Nerve Tissue Proteins / chemistry*,  physiology*
Protein Structure, Tertiary
Recombinant Fusion Proteins / chemistry
Grant Support
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/KIF1A protein, human; 0/Kif1a protein, rat; 0/Liposomes; 0/Molecular Motor Proteins; 0/Nerve Tissue Proteins; 0/Recombinant Fusion Proteins; 0/UNC-104 protein, C elegans; EC 3.6.1.-/Kinesin

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