Document Detail

Conversion of dehydroepiandrosterone sulphate to oestrogens in intraphepatic cholestasis and other complications of pregnancy.
MedLine Citation:
PMID:  6446991     Owner:  NLM     Status:  MEDLINE    
The aim of the present study was to determine whether pregnancy complications themselves influence the conversion rate of dehydroepiandrosterone sulphate (DHAS) to oestrogens during pregnancy. 100 mg DHAS was given intravenously to seven women with intrahepatic cholestasis of pregnancy, nine women with preeclampsia, nine diabetics, ten with twins and eight women with normal pregnancy between 31--40 weeks of gestation. Serum oestradiol (E2) and oestriol (E3) were measured with specific radioimmunoassays before and 1--5 h after DHAS injections. A significant oestradiol elevation following DHAS was similar in each group. By contrast there was an oestriol elevation (P less than 0.05) only in intrahepatic cholestasis of pregnancy. The results indicate that: (1) pregnancy complication itself does not effect the conversion rate of DHAS to oestradiol, (2) in patients with intrahepatic cholestasis there is a disturbed E3 metabolism which may be due to an increased placental permeability to exogenous DHAS or to a decreased metabolism of E3 by maternal liver.
P Ylöstalo; A Kauppila; M Reinilä; R Tuimala; O Ylikorkala
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  12     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1980 Feb 
Date Detail:
Created Date:  1980-10-21     Completed Date:  1980-10-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  121-6     Citation Subset:  IM    
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MeSH Terms
Cholestasis, Intrahepatic / blood*
Dehydroepiandrosterone / blood*,  diagnostic use
Estradiol / blood*
Estriol / blood*
Pre-Eclampsia / blood*
Pregnancy Complications / blood*
Pregnancy Trimester, Third
Pregnancy in Diabetics / blood
Pregnancy, Multiple
Reg. No./Substance:
50-27-1/Estriol; 50-28-2/Estradiol; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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