| Conversion of dehydrodiferulic acids by human intestinal microbiota. | |
| | |
MedLine Citation:
|
PMID: 19275157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Plant cell wall associated dehydrodiferulic acids (DFA) are abundant components of cereal insoluble dietary fibers ingested by humans. The ability of human intestinal microbiota to convert DFA was studied in vitro by incubating 8-O-4- and 5-5-coupled DFA with fecal suspensions. 8-O-4-DFA was completely degraded by the intestinal microbiota of the majority of donors, yielding homovanillic acid, 3-(3,4-dihydroxyphenyl)propionic acid, and 3,4-dihydroxyphenylacetic acid as the main metabolites. The transient formation of ferulic acid and presumably 3-(3-hydroxy-4-methoxyphenyl)pyruvic acid suggests an initial cleavage of the ether bond. In contrast to 8-O-4-DFA, the 5-5-coupled DFA was not cleaved into monomers by any of the fecal suspensions. Only the side chains were hydrogenated and the methoxy groups were demethylated. The cleavage of DFA by human intestinal microbiota, which depended on their coupling type, may affect both the bioavailability of DFA and the degradability of DFA-coupled fiber in the gut. |
| | |
Authors:
|
Annett Braune; Mirko Bunzel; Reiko Yonekura; Michael Blaut |
Related Documents
:
|
3363297 - Intestinal absorption of phosphatidylcholine and triglyceride after ileal resection. 1732517 - Decorporation of aged americium deposits by oral administration of lipophilic polyamino... 3190437 - Quantitative measurement of endogenous amino acid absorption in unanaesthetized pigs. 8229687 - Characterization of the oral absorption of some beta-lactams: effect of the alpha-amino... 16466087 - Government-industry partnership in weekly iron-folic acid supplementation for women of ... 17530897 - Enantioselective fluorescent recognition of chiral acids by cyclohexane-1,2-diamine-bas... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of agricultural and food chemistry Volume: 57 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-04-16 Completed Date: 2009-07-16 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 3356-62 Citation Subset: IM |
Affiliation:
|
Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. braune@dife.de |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
3,4-Dihydroxyphenylacetic Acid
/
metabolism Cereals / chemistry Coumaric Acids / analysis, metabolism* Dietary Fiber / analysis Feces / microbiology Homovanillic Acid / metabolism Humans Intestines / microbiology* |
| Chemical | |
Reg. No./Substance:
|
0/5,5-dehydroferulic acid; 0/8-O-4-dehydrodiferulic acid; 0/Coumaric Acids; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dumbbell-like Au-Fe3O4 nanoparticles for target-specific platin delivery.
Next Document: Comparison of quantum dynamics and quantum transition state theory estimates of the H + CH4 reaction...