Document Detail

Conversion of dehydrodiferulic acids by human intestinal microbiota.
MedLine Citation:
PMID:  19275157     Owner:  NLM     Status:  MEDLINE    
Plant cell wall associated dehydrodiferulic acids (DFA) are abundant components of cereal insoluble dietary fibers ingested by humans. The ability of human intestinal microbiota to convert DFA was studied in vitro by incubating 8-O-4- and 5-5-coupled DFA with fecal suspensions. 8-O-4-DFA was completely degraded by the intestinal microbiota of the majority of donors, yielding homovanillic acid, 3-(3,4-dihydroxyphenyl)propionic acid, and 3,4-dihydroxyphenylacetic acid as the main metabolites. The transient formation of ferulic acid and presumably 3-(3-hydroxy-4-methoxyphenyl)pyruvic acid suggests an initial cleavage of the ether bond. In contrast to 8-O-4-DFA, the 5-5-coupled DFA was not cleaved into monomers by any of the fecal suspensions. Only the side chains were hydrogenated and the methoxy groups were demethylated. The cleavage of DFA by human intestinal microbiota, which depended on their coupling type, may affect both the bioavailability of DFA and the degradability of DFA-coupled fiber in the gut.
Annett Braune; Mirko Bunzel; Reiko Yonekura; Michael Blaut
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  57     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-07-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3356-62     Citation Subset:  IM    
Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Cereals / chemistry
Coumaric Acids / analysis,  metabolism*
Dietary Fiber / analysis
Feces / microbiology
Homovanillic Acid / metabolism
Intestines / microbiology*
Reg. No./Substance:
0/5,5-dehydroferulic acid; 0/8-O-4-dehydrodiferulic acid; 0/Coumaric Acids; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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