Document Detail


Conversion of benzylpenicillin to penicilloic acid in patients with chronic bronchial infections.
MedLine Citation:
PMID:  1253635     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A colorimetric method was modified to estimate the levels of benzylpenicillin and its penicilloic acid in urine. When benzylpenicillin was given orally to healthy volunteers, both it and its penicilloic acid were detected in the urine. When benzylpenicillin was given by intramuscular injections to these volunteers, only benzylpenicillin was detected in the urine. Patients suffering from chronic bronchial infections that exhibited beta-lactamase producing gram-negative bacteria in their sputum were given benzylpenicillin intramuscularly. It was found that both benzylpenicillin and penicilloic acid were recovered from the urine of such patients.
Authors:
A Ingold
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemotherapy     Volume:  22     ISSN:  0009-3157     ISO Abbreviation:  Chemotherapy     Publication Date:  1976  
Date Detail:
Created Date:  1976-05-10     Completed Date:  1976-05-10     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0144731     Medline TA:  Chemotherapy     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  88-96     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Bacterial Infections / drug therapy*
Bronchitis / drug therapy*
Carboxylic Acids / urine
Chronic Disease
Colorimetry
Enterobacteriaceae / enzymology
Humans
Injections, Intramuscular
Male
Middle Aged
Penicillin G / administration & dosage,  metabolism*,  therapeutic use
Penicillinase / metabolism
Sputum / microbiology
Thiazoles / urine*
Chemical
Reg. No./Substance:
0/Carboxylic Acids; 0/Thiazoles; 61-33-6/Penicillin G; EC 3.5.2.-/Penicillinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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