Document Detail

Conversion of atrial fibrillation to sinus rhythm and rate control by digoxin in comparison to placebo.
MedLine Citation:
PMID:  9129896     Owner:  NLM     Status:  MEDLINE    
AIMS: A randomized, double-blind study with a high dose of digoxin administered intravenously for conversion of atrial fibrillation (not due to haemodynamic alternations) to sinus rhythm, and for rate control in converters and non-converters was set up. Outcome measures were conversion within 12 h; time to conversion; early rate control; and stable slowing within 12 h. METHODS: We studied 40 patients with recent onset (< 1 week) atrial fibrillation; controls received saline intravenously, the other patients digoxin 1.25 mg. RESULTS: One patient converted before digoxin administration. Conversion occurred in 9/19 patients on digoxin and in 8/20 on placebo (ns). The mean time to conversion tended to be shorter only for digoxin. Two late conversions on placebo were observed within 24 h. Heart rate during atrial fibrillation decreased after 30 min for converters and non-converters (P < 0.05). For all patients on digoxin, heart rate after 30 min was lower compared to baseline (P < 0.002) and to placebo (P < 0.02). Persistent, stable slowing occurred only in 3/10 non-converters on digoxin (P < 0.05), and two patients developed bradyarrhythmias. QTc was shortened immediately after conversion in all patients. Converters had baseline characteristics similar to those of non-converters. CONCLUSIONS: Intravenous digoxin offers no substantial advantages over placebo in recent onset atrial fibrillation with respect to conversion, and provides weak rate control.
L Jordaens; J Trouerbach; P Calle; R Tavernier; E Derycke; P Vertongen; B Bergez; Y Vandekerckhove
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  18     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-17     Completed Date:  1997-07-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  643-8     Citation Subset:  IM    
Department of Cardiology, University Hospital, Ghent, Belgium.
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MeSH Terms
Aged, 80 and over
Anti-Arrhythmia Agents / administration & dosage*,  adverse effects
Atrial Fibrillation / drug therapy*,  etiology
Digoxin / administration & dosage*,  adverse effects
Dose-Response Relationship, Drug
Double-Blind Method
Electrocardiography / drug effects*
Follow-Up Studies
Heart Rate / drug effects
Infusions, Intravenous
Middle Aged
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 20830-75-5/Digoxin
Comment In:
Eur Heart J. 1997 Apr;18(4):546-7   [PMID:  9129879 ]

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