| Conversion of 4-aminobutyraldehyde to gamma-aminobutyric acid in striatum treated with semicarbazide and kainic acid. | |
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MedLine Citation:
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PMID: 3785548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4-Aminobutyraldehyde (ABAL) has been shown to cross the blood-brain barrier and to be converted rapidly to gamma-aminobutyric acid (GABA) in various regions of the brain. In this paper, the formation of GABA from ABAL was studied with striatum that had suffered a lesion to GABA synthesis via glutamic acid decarboxylase (GAD). The GABA formation from ABAL was invariably observed in striatum in which GAD was severely inhibited by semicarbazide or kainic acid. Thus, this is another pathway for GABA formation. |
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Authors:
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S Matsushima; S Hori; M Matsuda |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Neurochemical research Volume: 11 ISSN: 0364-3190 ISO Abbreviation: Neurochem. Res. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1987-01-02 Completed Date: 1987-01-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7613461 Medline TA: Neurochem Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1313-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aldehydes
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metabolism* Animals Corpus Striatum / drug effects, metabolism* Glutamate Decarboxylase / antagonists & inhibitors, metabolism Kainic Acid / pharmacology Male Rats Semicarbazides / pharmacology gamma-Aminobutyric Acid / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Semicarbazides; 4390-05-0/4-aminobutyraldehyde; 487-79-6/Kainic Acid; 56-12-2/gamma-Aminobutyric Acid; 57-56-7/carbamylhydrazine; EC 4.1.1.15/Glutamate Decarboxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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