Document Detail


Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.
MedLine Citation:
PMID:  23776758     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chordomas of the skull base are rare locally aggressive neoplasms with a predilection for encapsulating critical neurovascular structures, bony destruction and irregular growth patterns, and from which patients succumb to recurrence and treatment failures.
METHODS: A review of the medical literature is performed, using standard search engines and identifying articles related to skull base chordomas, surgery, radiation therapy, chemotherapy, molecular genetics, and prospective trials.
RESULTS: A synthesis of the literature is presented, including sections on pathology, treatment, molecular genetics, challenges, and future directions.
CONCLUSION: Beyond an understanding of the current treatment paradigms for skull base chordomas, the reader gains insight into the collaborative approach applied to orphan diseases, of which chordomas is a prime exemplar.
Authors:
Salvatore Di Maio; Esther Kong; Stephen Yip; Robert Rostomily
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Publication Detail:
Type:  Journal Article     Date:  2013-06-01
Journal Detail:
Title:  Surgical neurology international     Volume:  4     ISSN:  2229-5097     ISO Abbreviation:  Surg Neurol Int     Publication Date:  2013  
Date Detail:
Created Date:  2013-06-18     Completed Date:  2013-06-19     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  101535836     Medline TA:  Surg Neurol Int     Country:  India    
Other Details:
Languages:  eng     Pagination:  72     Citation Subset:  -    
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