Document Detail


Converging evidence for gamma synchrony deficits in schizophrenia.
MedLine Citation:
PMID:  24053039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In electroencephalogram (EEG) studies of auditory steady-state responses (ASSRs), patients with schizophrenia show a deficit in power and/or phase-locking, particularly at the 40 Hz frequency where these responses resonate. In addition, studies of the transient gamma-band response (GBR) elicited by single tones have revealed deficits in gamma power and phase-locking in schizophrenia. We examined the degree to which the 40 Hz ASSR and the transient GBR to single tones are correlated and whether they assess overlapping or distinct gamma-band abnormalities in schizophrenia.
METHODS: EEG was recorded during 40 Hz ASSR and auditory oddball paradigms from 28 patients with schizophrenia or schizoaffective disorder (SZ) and 25 age- and gender-matched healthy controls (HC). The ASSR was elicited by 500 ms click trains, and the transient GBR was elicited by the standard tones from the oddball paradigm. Gamma phase and magnitude values, calculated using Morlet wavelet transformations, were used to derive total power and phase-locking measures.
RESULTS: Relative to HC, SZ patients had significant deficits in total gamma power and phase-locking for both ASSR- and GBR-based measures. Within both groups, the 40 Hz ASSR and GBR phase-locking measures were significantly correlated, with a similar trend evident for the total power measures. Moreover, co-varying for GBR substantially reduced 40 Hz ASSR power and phase-locking differences between the groups.
CONCLUSIONS: 40 Hz ASSR and transient GBR measures provide very similar information about auditory gamma abnormalities in schizophrenia, despite the overall enhancement of 40 Hz ASSR total power and phase-locking values relative to the corresponding GBR values.
Authors:
B J Roach; J M Ford; R E Hoffman; D H Mathalon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Supplements to Clinical neurophysiology     Volume:  62     ISSN:  1567-424X     ISO Abbreviation:  Suppl Clin Neurophysiol     Publication Date:  2013  
Date Detail:
Created Date:  2013-09-23     Completed Date:  2013-10-22     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  100967410     Medline TA:  Suppl Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  163-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Adult
Analysis of Variance
Auditory Perceptual Disorders / etiology*
Brain Mapping*
Brain Waves / physiology*
Case-Control Studies
Electroencephalography
Evoked Potentials, Auditory / physiology*
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
Psychoacoustics
Reaction Time
Schizophrenia / complications*,  diagnosis
Time Factors
Young Adult
Grant Support
ID/Acronym/Agency:
R01 MH058262/MH/NIMH NIH HHS
Comments/Corrections

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