| Convergent, not serial, striatal and pallidal circuits regulate opioid-induced food intake. | |
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MedLine Citation:
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PMID: 19336249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mu opioid receptor (MOR) signaling in the nucleus accumbens (NAcc) elicits marked increases in the consumption of palatable tastants. However, the mechanism and circuitry underlying this effect are not fully understood. Multiple downstream target regions have been implicated in mediating this effect but the role of the ventral pallidum (VP), a primary target of NAcc efferents, has not been well defined. To probe the mechanisms underlying increased consumption, we identified behavioral changes in rats' licking patterns following NAcc MOR stimulation. Because the temporal structure of licking reflects the physiological substrates modulating consumption, these measures provide a useful tool in dissecting the cause of increased consumption following NAcc MOR stimulation. Next, we used a combination of pharmacological inactivation and lesions to define the role of the VP in hyperphagia following infusion of the MOR-specific agonist [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) into the NAcc. In agreement with previous studies, results from lick microstructure analysis suggest that NAcc MOR stimulation augments intake through a palatability-driven mechanism. Our results also demonstrate an important role for the VP in normal feeding behavior: pharmacological inactivation of the VP suppresses baseline and NAcc DAMGO-induced consumption. However, this interaction does not occur through a serial circuit requiring direct projections from the NAcc to the VP. Rather, our results indicate that NAcc and VP circuits converge on a common downstream target that regulates food intake. |
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Authors:
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S A Taha; Y Katsuura; D Noorvash; A Seroussi; H L Fields |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-03-29 |
Journal Detail:
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Title: Neuroscience Volume: 161 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-01 Completed Date: 2009-08-24 Revised Date: 2012-12-17 |
Medline Journal Info:
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Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
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Languages: eng Pagination: 718-33 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. s.taha@utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Catheterization Eating / drug effects, physiology* Enkephalin, Ala(2)-MePhe(4)-Gly(5)- / administration & dosage Feeding Behavior / drug effects, physiology GABA Agonists / administration & dosage Globus Pallidus / drug effects, physiology* Hyperphagia / chemically induced, physiopathology Male Motor Activity / drug effects, physiology Muscimol / administration & dosage Neural Pathways / drug effects, physiology Neurotoxins / toxicity Neurotransmitter Agents / administration & dosage Nucleus Accumbens / drug effects, physiology* Quinolinic Acid / toxicity Random Allocation Rats Rats, Long-Evans Receptors, Opioid, mu / agonists, metabolism* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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R21 MH082325/MH/NIMH NIH HHS; R21 MH082325-02/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/GABA Agonists; 0/Neurotoxins; 0/Neurotransmitter Agents; 0/Receptors, Opioid, mu; 100929-53-1/Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; 2763-96-4/Muscimol; 89-00-9/Quinolinic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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