Document Detail

Conventional vs high-frequency jet ventilation in a piglet model of meconium aspiration: comparison of pulmonary and hemodynamic effects.
MedLine Citation:
PMID:  3891945     Owner:  NLM     Status:  MEDLINE    
The pulmonary and cardiovascular effects of high-frequency jet (HFJV) and conventional (CV) ventilation were evaluated in a piglet model of meconium aspiration. A mixture of 20% human meconium and 0.9% saline solution was instilled deep into the trachea of 10 piglets, after which either HFJV or CV was administered for 4 hours. Arterial blood gases, cardiac output, mean pulmonary and systemic arterial pressures, pulmonary and systemic vascular resistances, and pulmonary mechanics were compared between groups. During the 4 hours of ventilation, PaO2 and PaCO2 were not statistically different between groups. The peak inspiratory pressure necessary to maintain PaCO2 in the preset range was approximately half as much in the HFJV group as in the CV group (P less than 0.002). Mean airway pressure was lower in the HFJV group only during the second hour (P less than 0.03). Cardiac output, mean aortic and pulmonary artery pressures, systemic and pulmonary vascular resistance, dynamic lung compliance, and pulmonary resistance were not statistically different between groups. Our results suggest that HFJV may be more effective than CV in the early stages of meconium aspiration syndrome because HFJV allows more efficient ventilation and adequate oxygenation at lower peak inspiratory pressures.
O Trindade; R N Goldberg; E Bancalari; P Dickstein; J Ellison; T Gerhardt
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  107     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-16     Completed Date:  1985-08-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  115-20     Citation Subset:  AIM; IM    
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MeSH Terms
Animals, Newborn
Disease Models, Animal
Infant, Newborn
Intermittent Positive-Pressure Breathing / adverse effects
Pneumonia, Aspiration / etiology,  therapy*
Respiration, Artificial / adverse effects,  methods*
Respiratory Function Tests
Grant Support
1 RO1 HD14940-03/HD/NICHD NIH HHS; 5 RO1 HL25023-03/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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