Document Detail


Conventional ultrasound integrated with elastosonography and B-flow imaging in the diagnosis of thyroid nodular lesions.
MedLine Citation:
PMID:  24862678     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this study was to evaluate the sonographic features of thyroid nodules suspicious for malignancy with standard examination in B-mode and Color Doppler associated with modern techniques such as ultrasound RTE (Real Time Elastosonography) and BFI (B-flow imaging) in correlation with the results of the sonographically guided fine-needle aspiration to establish their role in predicting the risk of malignancy. Between November 2012 and January 2014, 354 consecutive patients (age range, 18-73 years; mean age ± SD, 41.2 ± 9.2 years; 90 male and 264 female) with 493 suspected nodules (maximum diameter > 9 mm) were enrolled in this prospective study. Sonographic, elastosonographic and BFI examinations were performed with a commercially available real-time ultrasound system, and all patients also underwent a cytologic evaluation. Patients with suspicious or malignant cytologic features underwent surgery. On histologic examination, 71 of 493 nodules were malignant (62 papillary thyroid carcinoma, 1 Hürthle cell carcinoma, and 8 follicular carcinoma). All sonographic characteristics, which were potential predictors of thyroid malignancy (microcalcifications, hypoechogenicity, absence of a halo, and a predominantly solid composition), were found in different percentages in both histologically verified malignant and benign nodules. For BFI, pattern 3 (≥4 signs and distance > 2 mm) was the most predictive factor for malignancy (specificity, 99.6%; sensitivity, 65.2%), whereas pattern 2 (≥4 signs and distance < 2 mm) was a positive factor because it was detected only in benign lesions. For the RTE, scores 1-2 were detected in 68% of benign nodules, while scores 3-4 in 94% of malignant nodules. Our results indicate that Elastosonography and BFI can overcome the limits of the traditional B-mode and color Doppler sonographic features in the diagnosis of thyroid nodules. This techniques provides maximum specificity levels both in the case of benign nodules and in the case of malignant nodules.
Authors:
Alfonso Reginelli; Fabrizio Urraro; Graziella di Grezia; Giuseppina Napolitano; Nicola Maggialetti; Salvatore Cappabianca; Luca Brunese; Ettore Squillaci
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-23
Journal Detail:
Title:  International journal of surgery (London, England)     Volume:  -     ISSN:  1743-9159     ISO Abbreviation:  Int J Surg     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101228232     Medline TA:  Int J Surg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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