Document Detail


Conventional and molecular cytogenetic features of myelodysplastic syndrome in China.
MedLine Citation:
PMID:  18199987     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Myelodysplastic syndrome (MDS) constitutes a heterogeneous group of hematopoietic stem cell disorder characterized by peripheral blood cytopenia(s), in the presence of hypercellular bone marrow with features of ineffective hematopoiesis, and susceptibility to acute leukemia (AL). Although the precise pathogenesis of MDS remains to be clarified, cytogenetic abnormalities seem to be involved in its pathogenesis and are considered as an important factor in diagnosis and predicting clinical outcome. OBJECTIVE: To explore the cytogenetic features of Chinese patients with myelodysplastic syndrome (MDS). METHODS: Conventional cytogenetic analysis was performed in 88 MDS patients and among them, 34 cases were studied by interphase fluorescence in situ hybridization (I-FISH) with precisely chromosome 8 centromere specific DNA probe and DNA specific probes for 7q32 , 5q31. RESULTS: Of the 88 patients, 45 (51.1%) showed clonal karyotypic abnormalities by CC at diagnosis, including numerical changes (18 cases, 20.5%), structural changes (12 cases, 13.6%), and numerical and structural changes simultaneously(15 cases, 17.0%). Trisomy 8, -5/5q-, and -7/ 7q- account for 20.5%, 15.9%, and 5.7% respectively. Complex karyotypes were observed in 17 patients, the incidence being 19.3% in the whole series of cases. Among 34 MDS patients studied by I-FISH, -5/5q-, -7/7q- and trisomy 8 occurring in 4, 2 and 10 cases respectively for CC were confirmed by I-FISH. 5 cases in 30 cases who did not show -5/5q- by CC displayed this abnormality by I-FISH. 3 cases without -7/7q- by CC presented this aberration by I-FISH. 5 cases with trisomy 8 for I-FISH was not identified this change by CC. CONCLUSIONS: The frequent abnormalities are trisomy 8, -5/5q- and -7/ 7q-. FISH is very useful in detecting these alterations in MDS and it is an important complement to CC.
Authors:
L- J Chen; J- Y Li; Y Zhu; H- R Qiu; J- L Pan; R Wang; S- X Qian; W Xu; Y- Q Xue
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental oncology     Volume:  29     ISSN:  1812-9269     ISO Abbreviation:  Exp. Oncol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-01-17     Completed Date:  2008-04-08     Revised Date:  2010-01-15    
Medline Journal Info:
Nlm Unique ID:  101230541     Medline TA:  Exp Oncol     Country:  Ukraine    
Other Details:
Languages:  eng     Pagination:  299-303     Citation Subset:  IM    
Affiliation:
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China. lijianyonglm@medmail.com.cn
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
China
Chromosome Aberrations
Chromosome Banding
Chromosomes, Human, Pair 5 / genetics*
Chromosomes, Human, Pair 7 / genetics*
Chromosomes, Human, Pair 8 / genetics*
Cytogenetic Analysis*
Female
Humans
In Situ Hybridization, Fluorescence
Male
Middle Aged
Myelodysplastic Syndromes / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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