Document Detail


Conventional frequency ultrasonic biomarkers of cancer treatment response in vivo.
MedLine Citation:
PMID:  23761215     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Conventional frequency quantitative ultrasound in conjunction with textural analysis techniques was investigated to monitor noninvasively the effects of cancer therapies in an in vivo preclinical model.
METHODS: Conventional low-frequency (∼7 MHz) and high-frequency (∼20 MHz) ultrasound was used with spectral analysis, coupled with textural analysis on spectral parametric maps, obtained from xenograft tumor-bearing animals (n = 20) treated with chemotherapy to extract noninvasive biomarkers of treatment response.
RESULTS: Results indicated statistically significant differences in quantitative ultrasound-based biomarkers in both low- and high-frequency ranges between untreated and treated tumors 12 to 24 hours after treatment. Results of regression analysis indicated a high level of correlation between quantitative ultrasound-based biomarkers and tumor cell death estimates from histologic analysis. Applying textural characterization to the spectral parametric maps resulted in an even stronger correlation (r (2) = 0.97).
CONCLUSION: The results obtained in this research demonstrate that quantitative ultrasound at a clinically relevant frequency can monitor tissue changes in vivo in response to cancer treatment administration. Using higher order textural information extracted from quantitative ultrasound spectral parametric maps provides more information at a high sensitivity related to tumor cell death.
Authors:
Ali Sadeghi-Naini; Omar Falou; Hadi Tadayyon; Azza Al-Mahrouki; William Tran; Naum Papanicolau; Michael C Kolios; Gregory J Czarnota
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Publication Detail:
Type:  Journal Article     Date:  2013-06-01
Journal Detail:
Title:  Translational oncology     Volume:  6     ISSN:  1936-5233     ISO Abbreviation:  Transl Oncol     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-13     Completed Date:  2013-06-14     Revised Date:  2014-02-28    
Medline Journal Info:
Nlm Unique ID:  101472619     Medline TA:  Transl Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  234-43     Citation Subset:  -    
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Erratum In:
Transl Oncol. 2013 Dec;6(6):erratum

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