| Conventional and controlled release valproate in children with epilepsy: a cross-over study comparing plasma levels and cognitive performances. | |
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MedLine Citation:
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PMID: 1493787 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied plasma levels and behavioural effects of a newly developed controlled release formulation of valproate (VPA-CR) in children with epilepsy. Valproate plasma levels and performances in attention and vigilance tasks were monitored during a 12-h period (daytime), both during monotherapy of conventional valproate (VPA) and 4 weeks after switching to a similar dosage of VPA-CR taken once daily. There was no significant difference between the two formulations with respect to mean diurnal trough and peak valproate plasma levels, and to mean fluctuation. The significantly higher Cmax/Cmin ratio during VPA-CR seems mainly due to low valproate plasma levels early in the morning. Neuropsychological assessment showed no significant differences, either between patients and controls, or within patients and controls when comparing the results obtained on the VPA and VPA-CR day. During both VPA and VPA-CR treatment, no correlation was found between cognitive performance and valproate plasma levels. The advantage of VPA-CR is that the once daily regimen may increase compliance and is more convenient for schoolchildren. |
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Authors:
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O F Brouwer; M S Pieters; P M Edelbroek; A M Bakker; A A van Geel; T Stijnen; A Jennekens-Schinkel; J B Lanser; A C Peters |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Epilepsy research Volume: 13 ISSN: 0920-1211 ISO Abbreviation: Epilepsy Res. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-03-08 Completed Date: 1993-03-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8703089 Medline TA: Epilepsy Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 245-53 Citation Subset: IM |
Affiliation:
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Department of Neurology, University Hospital, Leiden, Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Attention / drug effects Child Child, Preschool Cognition / drug effects* Delayed-Action Preparations Epilepsy / blood, drug therapy*, psychology Female Humans Male Neuropsychological Tests Psychomotor Performance / drug effects Valproic Acid / blood, pharmacokinetics, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 99-66-1/Valproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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