Document Detail


Conventional antigen and superantigen may be coupled to distinct and cooperative T-cell activation pathways.
MedLine Citation:
PMID:  1681539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CD4+ T cells are equipped to detect two major classes of ligands. Infectious microbial agents, including bacteria and retroviruses, carry a class of proteins termed superantigens that are recognized by the T-cell receptor in association with class II products of the major histocompatibility complex. Proteins expressed by other cells and organisms are processed by macrophages into peptides that are presented to CD4+ T cells by class II molecules. We have examined CD4+ T-cell clones that proliferate vigorously in response both to conventional peptide antigens and to bacterial or retroviral superantigens. The response to peptide antigen is characterized by a rapid and sustained increase in the levels of intracellular free Ca2+ and a vigorous cytokine response. In contrast, the proliferative response of these clones to bacterial or retroviral superantigen is not accompanied by detectable increases in intracellular Ca2+ or by significant cytokine production. Further analysis of T-cell activation indicates that interaction of a single T-cell receptor with the two types of ligand may be coupled to functionally distinct signaling pathways that interact in a synergistic fashion to achieve T-cell activation.
Authors:
H Liu; M A Lampe; M V Iregui; H Cantor
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  88     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-10-31     Completed Date:  1991-10-31     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8705-9     Citation Subset:  IM    
Affiliation:
Department of Pathology, Harvard Medical School, Boston, MA 02115.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigen-Presenting Cells / immunology
Antigens / immunology*
CD4-Positive T-Lymphocytes / immunology*
Calcium / physiology
Clone Cells
Enterotoxins / immunology
Interleukin-2 / metabolism
Interleukin-3 / metabolism
Ligands
Lymphocyte Activation*
Mice
Mice, Inbred Strains
Minor Lymphocyte Stimulatory Antigens / immunology
Ovalbumin / immunology
Receptors, Antigen, T-Cell / immunology*
Signal Transduction
T-Lymphocytes, Helper-Inducer / immunology*
Grant Support
ID/Acronym/Agency:
AI 12184/AI/NIAID NIH HHS; AI 13600/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens; 0/Enterotoxins; 0/Interleukin-2; 0/Interleukin-3; 0/Ligands; 0/Minor Lymphocyte Stimulatory Antigens; 0/Receptors, Antigen, T-Cell; 39424-53-8/enterotoxin B, staphylococcal; 7440-70-2/Calcium; 9006-59-1/Ovalbumin
Comments/Corrections

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