| The Conventional Langmuir Trough Technique as a Convenient Means to Determine the Solubility of Sparingly Soluble Surface Active Molecules: Case Study Cholesterol. | |
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MedLine Citation:
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PMID: 19609337 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The feasibility of a method based on mass preservation [G. Schwarz, J. Zhang, Chem. Phys. Lipids, 110 (2001) 35-45] to determine the solubility of Cholesterol in water from monomolecular films on air/water interface was investigated. Using a mass balance equation, it was found that Cholesterol undergoes an exponential desorption at very low surface pressures followed by an almost linear desorption into the subphase at higher surface pressures until monolayer collapse. Processing of the surface pressure measurements as a function of trough area in accord with the theory, enabled the accurate determination of the molecular dimensions of Cholesterol as a function of surface pressure. Slight modification of the theory enabled accurate quantification of the surface pressure-independent apparent solubility of Cholesterol and the amount of Cholesterol desorbed into the subphase as a function of surface pressure, in the nanomolar range. |
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Authors:
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Michalakis Savva; Balasubramanian Sivakumar; Bilge Selvi |
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Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Colloids and surfaces. A, Physicochemical and engineering aspects Volume: 325 ISSN: - ISO Abbreviation: Colloids Surf A Physicochem Eng Asp Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2009-7-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9891752 Medline TA: Colloids Surf A Physicochem Eng Asp Country: - |
Other Details:
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Languages: ENG Pagination: 1-6 Citation Subset: - |
Affiliation:
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Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY 11201, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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R15 EB004863-01A1//NIBIB NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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