Document Detail

Convenient murine pneumoperitoneal model for the study of laparoscopic cancer surgery.
MedLine Citation:
PMID:  10871177     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of laparoscopic surgery on the progression of cancers, it is necessary to establish a reliable and economical animal model. We describe a convenient murine pneumoperitoneal model for the study of laparoscopic cancer surgery. Under anesthesia using diethyl ether, peritoneal cavity was insufflated with gas through an intravenous catheter placed in the left lower quadrant. Syringe pump was used for continuous gas insufflation, and intraperitoneal pressure was measured. Intraperitoneal pressure increased and reached 10 cm H2O when 15 mL of CO2 gas was injected, but fell to 1 cm H2O 5 min after stopping the injection. When the continuous flow was adjusted by syringe pump between 20 and 160 mL/hour, intraperitoneal pressure was easily maintained at 8 cm H2O for >60 min. We believe that this murine model for pneumoperitoneum may be useful for the study of laparoscopic cancer surgery.
T Suematsu; A Shiromizu; K Yamaguchi; N Shiraishi; Y Adachi; S Kitano
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Surgical laparoscopy, endoscopy & percutaneous techniques     Volume:  9     ISSN:  1530-4515     ISO Abbreviation:  Surg Laparosc Endosc Percutan Tech     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2000-07-19     Completed Date:  2000-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888751     Medline TA:  Surg Laparosc Endosc Percutan Tech     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  279-81     Citation Subset:  IM    
Department of Surgery I, Oita Medical University, Japan.
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MeSH Terms
Laparoscopy / methods*
Mice, Inbred BALB C
Neoplasm Seeding
Pneumoperitoneum, Artificial / methods*
Sensitivity and Specificity

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