Document Detail


Convective tissue movements play a major role in avian endocardial morphogenesis.
MedLine Citation:
PMID:  22280991     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Endocardial cells play a critical role in cardiac development and function, forming the innermost layer of the early (tubular) heart, separated from the myocardium by extracellular matrix (ECM). However, knowledge is limited regarding the interactions of cardiac progenitors and surrounding ECM during dramatic tissue rearrangements and concomitant cellular repositioning events that underlie endocardial morphogenesis. By analyzing the movements of immunolabeled ECM components (fibronectin, fibrillin-2) and TIE1 positive endocardial progenitors in time-lapse recordings of quail embryonic development, we demonstrate that the transformation of the primary heart field within the anterior lateral plate mesoderm (LPM) into a tubular heart involves the precise co-movement of primordial endocardial cells with the surrounding ECM. Thus, the ECM of the tubular heart contains filaments that were associated with the anterior LPM at earlier developmental stages. Moreover, endocardial cells exhibit surprisingly little directed active motility, that is, sustained directed movements relative to the surrounding ECM microenvironment. These findings point to the importance of large-scale tissue movements that convect cells to the appropriate positions during cardiac organogenesis.
Authors:
Anastasiia Aleksandrova; Andras Czirók; Andras Szabó; Michael B Filla; M Julius Hossain; Paul F Whelan; Rusty Lansford; Brenda J Rongish
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-01-04
Journal Detail:
Title:  Developmental biology     Volume:  363     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  2012-04-13     Revised Date:  2014-09-13    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  348-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Connective Tissue / embryology*
Coturnix / embryology*
Endocardium / embryology*
Fibronectins / metabolism
Mesoderm / growth & development
Microfilament Proteins / metabolism
Morphogenesis
Organogenesis*
Receptor, TIE-1 / metabolism
Grant Support
ID/Acronym/Agency:
HL085694/HL/NHLBI NIH HHS; HL087136/HL/NHLBI NIH HHS; P20 RR016475/RR/NCRR NIH HHS; P20 RR016475-10/RR/NCRR NIH HHS; R01 HL085694-04/HL/NHLBI NIH HHS; R01 HL087136/HL/NHLBI NIH HHS; R01 HL087136-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fibronectins; 0/Microfilament Proteins; 0/fibrillin; EC 2.7.10.1/Receptor, TIE-1
Comments/Corrections

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