Document Detail

Convalescent stage coronary flow reserve and late myocardial morphologic outcomes in patients with first anterior acute myocardial infarction.
MedLine Citation:
PMID:  14993774     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Microvascular damage immediately after reperfusion therapy is an independent predictor of left ventricular function in patients with acute myocardial infarction (AMI). However, its recovery may vary among individuals and the relationship between convalescent stage microvasculature and late myocardial morphologic change is unclear. METHODS AND RESULTS: Patients treated with coronary angioplasty within 12 h of their first anterior AMI were enrolled in this study. Coronary flow reserve (CFR) was measured 3 weeks post AMI, in both branches of the left coronary artery: culprit (left anterior descending artery: LAD) and non-culprit (left circumflex artery: LCX). Left ventriculography was performed at 3 weeks and 6 months post AMI and compared. Seventeen patients showed abnormal CFR in the LAD (Group 1: CFR<2), whereas 20 patients showed normal CFR (Group 2: CFR >/=2). Percent changes of end-diastolic volume tended to be higher in Group 1 than in Group 2 (11.8+/-21.6% vs -1.3+/-14.4%, p=0.056), and %changes of end-systolic volume was significantly smaller in Group 2 (11.8+/-22.1% vs -8.7+/-25.1%, p<0.05). A statistically significant correlation was found between absolute and relative CFR in the LAD and %change of end-systolic volume (r=-0.58: p<0.001, and r=0.40: p<0.05, respectively). CONCLUSIONS: Microvascular function in the convalescent stage may be related to these favorable changes.
Yoshihisa Shimada; Minoru Yoshiyama; Hidemasa Tanaka; Hiroshi Sato; Ken Yoshida; Satoshi Jissho; Eiji Uchida; Kimio Kamimori; Yasuhiro Nakamura; Hidetaka Iida; Kazuhide Takeuchi; Junichi Yoshikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  68     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-02     Completed Date:  2004-09-28     Revised Date:  2005-12-02    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  208-13     Citation Subset:  IM    
Division of Cardiology, Tsukazaki Memorial Hospital, Hyogo, Japan.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Blood Flow Velocity / physiology
Coronary Circulation / physiology*
Coronary Vessels / physiopathology*,  surgery,  ultrasonography
Echocardiography, Doppler
Heart / physiopathology
Middle Aged
Myocardial Infarction / physiopathology*,  therapy*,  ultrasonography
Myocardial Reperfusion
Recovery of Function

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