Document Detail


A Contura catheter offers dosimetric advantages over a MammoSite catheter that increase the applicability of accelerated partial breast irradiation.
MedLine Citation:
PMID:  19736045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: The purpose of this study was to determine whether a Contura catheter (SenoRx, Inc, Aliso Viejo, CA) can increase the applicability of accelerated partial breast irradiation. METHODS AND MATERIALS: One hundred eighty-two women with early stage breast carcinomas were treated with postlumpectomy brachytherapy using a Contura multilumen catheter (n=45) or a MammoSite single-lumen catheter (Cytyc Corp, Marlborough, MA) (n=137). Hypothetical MammoSite catheter treatment plans were created for the Contura patients. Treatment planning goals were to (1) avoid a radiation "hot spot" in the skin and (2) have only a small air/fluid pocket next to the balloon. RESULTS: The median followup was 16 months. Eighty-nine percent (40 of 45) of Contura plans satisfied both treatment planning goals vs. only 36% (16 of 45) of MammoSite plans (p<0.0001). A Contura catheter did not require explantation in 16% (7 of 45) of patients where balloon-to-skin spacing was only 3-6mm and 11% (5 of 45) of patients where there was an air/fluid pocket >10% of the planning target volume for plan evaluation (PTV_EVAL). A MammoSite catheter was explanted in 10% of cases where the minimum balloon-to-skin distance was <7mm and in 13% of cases where there was a large air/fluid pocket next to the balloon. Our incidence rates of acute toxicity with a Contura catheter were similar to those with a MammoSite catheter. CONCLUSIONS: A Contura catheter provides important dosimetric advantages over a MammoSite catheter and does not require explantation in cases where balloon-to-skin spacing is only 3-6mm or an air/fluid pocket next to the balloon is >10% of PTV_EVAL.
Authors:
Richard B Wilder; Lisa D Curcio; Rajesh K Khanijou; Martin E Eisner; Jane L Kakkis; Lucy Chittenden; Jeffrey Agustin; Jessica Lizarde; Albert V Mesa; John Ravera; Kenneth M Tokita
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-06
Journal Detail:
Title:  Brachytherapy     Volume:  8     ISSN:  1538-4721     ISO Abbreviation:  Brachytherapy     Publication Date:    2009 Oct-Dec
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137600     Medline TA:  Brachytherapy     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-8     Citation Subset:  IM    
Affiliation:
Cancer Center of Irvine, Irvine, CA, USA. richardbwilder@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brachytherapy / adverse effects,  instrumentation*
Breast Neoplasms / radiotherapy*,  surgery
Female
Humans
Mastectomy, Segmental
Middle Aged
Radiation Injuries / etiology,  prevention & control*
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted
Radiotherapy, Adjuvant

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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