| Controversies surrounding xanthine therapy. | |
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MedLine Citation:
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PMID: 15050217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The methylxanthines aminophylline, theophylline and caffeine have been used for more than 30 years to treat apnoea of prematurity. Today, they are among the most commonly prescribed drugs in neonatal medicine. Methylxanthines reduce the frequency of idiopathic apnoea and the need for mechanical ventilation by acting as non-specific inhibitors of adenosine A(1) and A(2a) receptors. However, recent and rapidly growing research into the actions of adenosine and its receptors raises concerns about the safety of methylxanthine therapy in very preterm infants. Possible adverse effects include impaired growth, lack of neuroprotection during acute hypoxic-ischaemic episodes and abnormal behaviour. An international controlled clinical trial is underway to examine the long-term efficacy and safety of methylxanthine therapy in very low birth weight babies. |
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Authors:
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David Millar; Barbara Schmidt |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in neonatology : SN Volume: 9 ISSN: 1084-2756 ISO Abbreviation: Semin Neonatol Publication Date: 2004 Jun |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-09-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9606001 Medline TA: Semin Neonatol Country: England |
Other Details:
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Languages: eng Pagination: 239-44 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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therapeutic use Apnea / drug therapy* Central Nervous System Stimulants / adverse effects*, therapeutic use* Heart Rate / drug effects Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / drug therapy* Randomized Controlled Trials as Topic Vasodilator Agents / therapeutic use Xanthine / adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 0/Vasodilator Agents; 58-61-7/Adenosine; 69-89-6/Xanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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