Document Detail

Controversies in the use of drug-eluting stents for acute myocardial infarction: a critical appraisal of the data.
MedLine Citation:
PMID:  20059336     Owner:  NLM     Status:  MEDLINE    
Acute myocardial infarction is a common and life-threatening presentation of coronary artery disease in adults. In the settings of ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction, significant mortality benefit has been observed in randomized trials of coronary stent procedures compared with medical therapy alone. However, data regarding procedural choices, and particularly stent choices, are limited, and significant controversy exists. Drug-eluting stents were introduced in the United States in 2003 and have been widely adopted based on profound reduction in restenosis. Yet recent years have witnessed a decline in use of drug-eluting stents in the setting of myocardial infarction due to long-term safety concerns. We review the current data regarding drug-eluting stent performance relative to bare metal stents in the setting of acute myocardial infarction with regard to effectiveness, safety, and the need for adjunctive long-term pharmacologic therapy.
Rahul Sakhuja; Laura Mauri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annual review of medicine     Volume:  61     ISSN:  1545-326X     ISO Abbreviation:  Annu. Rev. Med.     Publication Date:  2010  
Date Detail:
Created Date:  2010-01-11     Completed Date:  2010-05-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985151R     Medline TA:  Annu Rev Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  215-31     Citation Subset:  IM    
Division of Cardiology, Massachusetts General Hospital, Boston, MA, USA.
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MeSH Terms
Angioplasty, Transluminal, Percutaneous Coronary*
Drug-Eluting Stents* / adverse effects
Graft Occlusion, Vascular / epidemiology*
Myocardial Infarction / etiology,  mortality,  therapy*
Platelet Aggregation Inhibitors / therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

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