| Controlling lipids in a high-risk population with documented coronary artery disease for secondary prevention: are we doing enough? | |
| | |
MedLine Citation:
|
PMID: 20305563 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The prevalence of high-density lipoprotein cholesterol (HDL-C) in patients who have achieved low-density lipoprotein cholesterol (LDL-C) targets in the current era of universal statin therapy remains unknown. We conducted a study to determine the prevalence of low HDL-C in patients with documented coronary artery disease, and to determine the lipid-lowering treatment patterns in secondary prevention of coronary artery disease. METHODS: In this retrospective cohort analysis, data were obtained from the electronic database of a cardiology clinic. The Joint British Society 2 criteria were used defining low HDL-C as less than 1 mmol/l in males and less than 1.2 mmol/l in females. We compared the prevalence of low HDL-C across the following categories of LDL-C: less than 2, 2-2.5, and greater than 2.5 mmol/l. RESULTS: Two thousand and eighty-seven patients with a mean age of 64.34±11.94 years constituted the study sample. About 36.6% of patients in this study were found to have low HDL-C. Irrespective of sex, low HDL-C was prevalent across all levels of LDL-C, but interestingly this was most prevalent in patients with a LDL-C less than 2 mmol/l (43.06%). HDL-C level of 1.16±0.97 mmol/l in patients with LDL-C less than 2 mmol/l was significantly lower than 1.22±0.33 mmol/l in patients with LDL-C greater than 2 mmol/l, P value less than 0.01. There was a poor correlation between levels of HDL-C and LDL-C in the study population irrespective of sex or statin therapy. CONCLUSION: This study shows widely prevalent low HDL-C levels in high-risk patients across the spectrum of LDL-C levels despite statin therapy. There was no correlation between the LDL-C and HDL-C levels implying their independent relationship and, thus, the need to treat them independently. |
| | |
Authors:
|
Mukesh Singh; Shui Hao Chin; Paul D Giles; David Crothers; Karim Al-Allaf; Jawad M Khan |
Related Documents
:
|
12438663 - The association between low birth weight and high levels of cholesterol is not due to a... 12548313 - Plant sterol-enriched spread enhances the cholesterol-lowering potential of a fat-reduc... 18425433 - The effect of peripheral administration of zinc on food intake in rats fed zn-adequate ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 17 ISSN: 1741-8275 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-05 Completed Date: 2011-02-01 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
|
Languages: eng Pagination: 556-61 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, Chicago Medical School, North Chicago, Ilinois 60064, USA. drmukeshsingh@yahoo.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Biological Markers / blood Chi-Square Distribution Cholesterol, HDL / blood Cholesterol, LDL / blood Coronary Artery Disease / etiology, prevention & control, therapy* Drug Utilization Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / blood, complications, drug therapy* Linear Models Male Middle Aged Physician's Practice Patterns* Practice Guidelines as Topic Recurrence / prevention & control Retrospective Studies Risk Assessment Risk Factors Secondary Prevention / methods* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Angiogenesis and vasculogenesis in rheumatoid arthritis.
Next Document: Depressive symptoms and heart rate variability in younger women after an acute coronary event.