Document Detail

Controlling the function of DNA nanostructures with specific trigger sequences.
MedLine Citation:
PMID:  23192255     Owner:  NLM     Status:  MEDLINE    
We report a hybridization-based switching mechanism with single-base specificity that can be readily integrated with functional DNA nanostructures. As an exemplar, we have developed a switchable DNAzyme (SDZ) that only becomes activated in the presence of a perfectly matched trigger sequence and operates effectively at room temperature.
Stijn Deborggraeve; Jian Yuan Dai; Yi Xiao; Hyongsok Tom Soh
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-11-28
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  49     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  2013-05-06     Revised Date:  2014-01-23    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  England    
Other Details:
Languages:  eng     Pagination:  397-9     Citation Subset:  IM    
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MeSH Terms
Base Pair Mismatch
Base Sequence
DNA / chemistry*,  genetics
DNA, Catalytic / chemistry*,  genetics
Models, Molecular
Molecular Sequence Data
Nanostructures / chemistry*
Nucleic Acid Hybridization
Optical Imaging
Grant Support
Reg. No./Substance:
0/DNA, Catalytic; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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