Document Detail

Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds.
MedLine Citation:
PMID:  16463173     Owner:  NLM     Status:  MEDLINE    
The antioxidative stress-response system is essential to fungi for tolerating exposure to phenolic compounds. We show how this system can be targeted to improve fungal control by using compounds that inhibit the fungal mitochondrial respiratory chain. Targeting mitochondrial superoxide dismutase with selected phenolic acid derivatives (e.g., vanillyl acetone) resulted in a 100- to 1,000-fold greater sensitivity to strobilurin or carboxin fungicides. This synergism is significantly greater with strobilurin than with carboxin, suggesting that complex III of the mitochondrial respiratory chain is a better target than complex II for fungal control, using phenolics. These results show certain natural compounds are effective synergists to commercial fungicides and can be used for improving control of food-contaminating pathogens. These results suggest that the use of such compounds for fungal control can reduce environmental and health risks associated with commercial fungicides, lower cost for control, and the probability for development of resistance.
Jong H Kim; Noreen Mahoney; Kathleen L Chan; Russell J Molyneux; Bruce C Campbell
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Publication Detail:
Type:  Journal Article     Date:  2006-02-07
Journal Detail:
Title:  Applied microbiology and biotechnology     Volume:  70     ISSN:  0175-7598     ISO Abbreviation:  Appl. Microbiol. Biotechnol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-08-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8406612     Medline TA:  Appl Microbiol Biotechnol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  735-9     Citation Subset:  IM    
Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, 800 Buchanan St., Albany, CA 94710, USA.
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MeSH Terms
Antifungal Agents / pharmacology
Antioxidants / pharmacology*
Aspergillus flavus / drug effects*,  enzymology
Aspergillus niger / drug effects*,  enzymology
Benzaldehydes / pharmacology
Carboxin / pharmacology
Cinnamates / pharmacology
Drug Synergism
Food Contamination*
Fungicides, Industrial / pharmacology
Gene Deletion
Guaiacol / analogs & derivatives,  pharmacology
Juglans / microbiology*
Microbial Sensitivity Tests
Mitochondria / enzymology
Phenols / pharmacology*
Saccharomyces cerevisiae / drug effects,  enzymology
Superoxide Dismutase / drug effects*,  metabolism
Thymol / pharmacology
Reg. No./Substance:
0/Antifungal Agents; 0/Antioxidants; 0/Benzaldehydes; 0/Cinnamates; 0/Fungicides, Industrial; 0/Phenols; 121-33-5/vanillin; 122-48-5/zingerone; 5234-68-4/Carboxin; 621-82-9/cinnamic acid; 89-83-8/Thymol; 90-05-1/Guaiacol; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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