| Controlling food-contaminating fungi by targeting their antioxidative stress-response system with natural phenolic compounds. | |
| | |
MedLine Citation:
|
PMID: 16463173 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The antioxidative stress-response system is essential to fungi for tolerating exposure to phenolic compounds. We show how this system can be targeted to improve fungal control by using compounds that inhibit the fungal mitochondrial respiratory chain. Targeting mitochondrial superoxide dismutase with selected phenolic acid derivatives (e.g., vanillyl acetone) resulted in a 100- to 1,000-fold greater sensitivity to strobilurin or carboxin fungicides. This synergism is significantly greater with strobilurin than with carboxin, suggesting that complex III of the mitochondrial respiratory chain is a better target than complex II for fungal control, using phenolics. These results show certain natural compounds are effective synergists to commercial fungicides and can be used for improving control of food-contaminating pathogens. These results suggest that the use of such compounds for fungal control can reduce environmental and health risks associated with commercial fungicides, lower cost for control, and the probability for development of resistance. |
| | |
Authors:
|
Jong H Kim; Noreen Mahoney; Kathleen L Chan; Russell J Molyneux; Bruce C Campbell |
Related Documents
:
|
8885323 - Survey of ethnic foods for mycotoxins. 9709253 - Occurrence of fumonisins in corn-based food products. 20954443 - Occurrence of listeria monocytogenes in ready-to-eat foods from supermarkets in souther... |
Publication Detail:
|
Type: Journal Article Date: 2006-02-07 |
Journal Detail:
|
Title: Applied microbiology and biotechnology Volume: 70 ISSN: 0175-7598 ISO Abbreviation: Appl. Microbiol. Biotechnol. Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-05-17 Completed Date: 2006-08-03 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8406612 Medline TA: Appl Microbiol Biotechnol Country: Germany |
Other Details:
|
Languages: eng Pagination: 735-9 Citation Subset: IM |
Affiliation:
|
Plant Mycotoxin Research Unit, Western Regional Research Center, USDA-ARS, 800 Buchanan St., Albany, CA 94710, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antifungal Agents
/
pharmacology Antioxidants / pharmacology* Aspergillus flavus / drug effects*, enzymology Aspergillus niger / drug effects*, enzymology Benzaldehydes / pharmacology Carboxin / pharmacology Cinnamates / pharmacology Drug Synergism Food Contamination* Fungicides, Industrial / pharmacology Gene Deletion Guaiacol / analogs & derivatives, pharmacology Juglans / microbiology* Microbial Sensitivity Tests Mitochondria / enzymology Phenols / pharmacology* Saccharomyces cerevisiae / drug effects, enzymology Superoxide Dismutase / drug effects*, metabolism Thymol / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Antioxidants; 0/Benzaldehydes; 0/Cinnamates; 0/Fungicides, Industrial; 0/Phenols; 121-33-5/vanillin; 122-48-5/zingerone; 5234-68-4/Carboxin; 621-82-9/cinnamic acid; 89-83-8/Thymol; 90-05-1/Guaiacol; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Whole-cell living biosensors--are they ready for environmental application?
Next Document: Keystone predators (eastern newts, Notophthalmus viridescens) reduce the impacts of an aquatic invas...