Document Detail


Controlling Anisotropic Drug Diffusion in Lipid- Fe3O4 Nanoparticle Hybrid Mesophases by Magnetic Alignment.
MedLine Citation:
PMID:  23302008     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We present a new strategy to control the anisotropic diffusion of hydrophilic drugs in lyotropic liquid crystals, via dispersion of magnetic nanoparticles in the mesophase, followed by re-orientation of the mesophase domains via an external magnetic field. We select a lipid reverse hexagonal phase doped with magnetic iron-oxide nanoparticles and glucose and caffeine, as model hybrid mesophase and hydrophilic drugs, respectively. Upon cooling through the disorder-order phase transition of the hexagonal phase and under the exposure to an external moderate magnetic field (1.1T), both the nanoparticles and the hexagonal domains align with their columnar axis along the field direction. As a result, the water nanochannels of the inverted hexagonal domains also align parallel to the field direction, leading to a drug diffusion coefficient parallel to the field direction much larger than what measured perpendicularly: in the case of glucose, for example, this difference in diffusion coefficients approaches one order of magnitude. Drug diffusion of the unaligned reverse hexagonal phase, which consists of random distributed domains, shows values in between the parallel and transversal diffusion. This study shows that modifying the overall alignment of anisotropic mesophases via moderate external fields is a valuable mean to control the corresponding transport tensor of the mesophase and demonstrates that the orientation of the domains plays an important role in the diffusion process of foreign hydrophilic molecules.
Authors:
Jijo J Vallooran; Renata Negrini; Raffaele Mezzenga
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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