Document Detail

Controlled trial of nutritional supplementation, with and without branched chain amino acid enrichment, in treatment of acute alcoholic hepatitis.
MedLine Citation:
PMID:  3932509     Owner:  NLM     Status:  MEDLINE    
Sixty-four patients admitted with acute alcoholic hepatitis, with or without underlying cirrhosis, were randomized regardless of encephalopathy to receive a controlled diet either alone, or supplemented orally, nasogastrically, or intravenously as necessary, with 2000 kCal and 10 g nitrogen daily. Whether this came from a conventional protein source or a branched chain amino acid enriched formulation was also randomly determined. In the absence of renal failure, nitrogen intakes of 10 g or more daily were invariably associated with positive nitrogen balance, but complications of liver dysfunction prevented the attainment of significantly more positive balance in the supplemented groups than in controls. Neither in the series as a whole, nor in any identifiable subgroup of patients, was mortality affected by treatment. Changes in prothrombin time and in measured nutritional parameters during the study did not differ between supplemented and control groups, and the observed changes in midarm muscle circumference appeared to reflect changes in degree of fluid retention. Neither enteral nor parenteral branched chain amino acids showed any consistent effect upon encephalopathy.
H Calvey; M Davis; R Williams
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hepatology     Volume:  1     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1985  
Date Detail:
Created Date:  1985-12-18     Completed Date:  1985-12-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  141-51     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Branched-Chain / administration & dosage*
Clinical Trials as Topic
Dietary Proteins / administration & dosage*
Enteral Nutrition
Follow-Up Studies
Food, Formulated
Food, Fortified
Hepatic Encephalopathy / diet therapy
Hepatitis, Alcoholic / diet therapy*
Liver Cirrhosis, Alcoholic / diet therapy
Liver Function Tests
Parenteral Nutrition, Total
Protein-Energy Malnutrition / diet therapy
Random Allocation
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Dietary Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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