Document Detail

Controlled trial of bright light for nonseasonal major depressive disorders.
MedLine Citation:
PMID:  1737074     Owner:  NLM     Status:  MEDLINE    
Psychotropic drug-free hospitalized veterans with nonseasonal major depressive disorders or depressed forms of bipolar disorder were treated with light for 1 week. Twenty-five patients were randomly assigned to bright white light treatment (2000-3000 lux), and 26 patients were randomized to dim red light placebo control treatment. Unlike those treated with dim red light, those treated with bright white light showed declines in three measures of depression during treatment. Partial relapse appeared within 2 days. A global depression score showed a statistically significant (p = 0.02) difference favoring bright white light treatment. Two bright-light-treated patients became mildly hypomanic, but side effects were mild. Improvement was not correlated with patient expectations; indeed, patients expected somewhat greater benefit from the placebo. Patients treated in summer responded as well as those treated in winter. Baseline electroencephalogram (EEG) sleep stage data (e.g., rapid eye movement; REM latency) did not predict treatment responses. These 1-week treatment results suggest that bright light might produce benefits for patients with nonseasonal depression. Bright light should not be recommended for routine clinical application before additional assessments with longer treatment durations are done.
D F Kripke; D J Mullaney; M R Klauber; S C Risch; J C Gillin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Biological psychiatry     Volume:  31     ISSN:  0006-3223     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-03-17     Completed Date:  1992-03-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-34     Citation Subset:  IM    
Department of Psychiatry, University of California, San Diego.
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MeSH Terms
Bipolar Disorder / therapy
Depressive Disorder / physiopathology,  psychology,  therapy*
Psychiatric Status Rating Scales
Sleep, REM / physiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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