Document Detail

Controlled trial of aspirin in cerebral ischemia.
MedLine Citation:
PMID:  324036     Owner:  NLM     Status:  MEDLINE    
Adouble-blind trial of aspirin for the treatment of cerebral ischemia was begun in 1972 and continued for 37 months. This was accomplished despite difficulties in controlling a long-term study of a drug which has widespread availability and consumption. The study design, criteria for selection of patients, follow-up surveillance, and methods of data analysis are presented. We report only subjects without carotid surgery before randomization. Patients (178) who had carotid transient ischemic attacks (TIAs) were randomly allocated to aspirin or placebo and followed to determine the incidence of subsequent TIAs,death, cerebral infarction or retinal infarction. Analysis of the first six months of follow-up revealed a statistically significant differential in favar of aspirin when death or cerebral or retinal infarction and the occurrence of TIAs were grouped and considered together as end points. Significance in favor of aspirin treatment was mainly revealed in patients with a history of multiple TIAs and was most evident in those individuals having carotid lesions appropriate to the TIA symptoms. It cannot be inferred from this study that aspirin prevents stroke because when end points were restriced to death or cerebral or retinal infarction, there was no statistically significant differential between the aspirin and placebo treatments.
W S Fields; N A Lemak; R F Frankowski; R J Hardy
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Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  8     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:    1977 May-Jun
Date Detail:
Created Date:  1977-06-30     Completed Date:  1977-06-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  301-14     Citation Subset:  IM    
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MeSH Terms
Aspirin / administration & dosage,  adverse effects,  therapeutic use*
Blindness / prevention & control
Cerebrovascular Disorders / mortality,  prevention & control
Clinical Trials as Topic
Follow-Up Studies
Ischemic Attack, Transient / drug therapy*,  mortality,  prevention & control
Middle Aged
Patient Compliance
Platelet Aggregation / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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