Document Detail


Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors.
MedLine Citation:
PMID:  17064428     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rate, risk, and predictors of switching from attention-deficit/hyperactivity disorder (ADHD) to a prepubertal and early adolescent bipolar I disorder phenotype (PEA-BP-I) were examined in a blindly rated, controlled, prospective 6-year follow-up that included assessments at 2-year intervals. Subjects were outpatients obtained by consecutive new case ascertainment. There were 81 subjects who were 9.7 +/- 2.0 years. Subjects had DSM-IV ADHD (hyperactive or combined subtypes); a Children's Global Assessment Scale (CGAS) score of < or =60, consistent with moderate-severe impairment; and no BP or major depressive disorder (MDD) diagnoses. PEA-BP-I was defined as DSM-IV BP I (manic or mixed phase), with cardinal symptoms (elation and/or grandiosity), to avoid diagnosing mania by symptoms that overlapped with those of ADHD, and by a CGAS score of < or =60. Morbid risk of switching to PEA-BP-I was 28.5%. Significant predictors of switching in a multivariate Cox model were more severe baseline CGAS, paternal recurrent MDD, and less stimulant use. BP I in first-degree relatives, antidepressants, psychosocial measures, and life events were not predictive.
Authors:
Rebecca Tillman; Barbara Geller
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Development and psychopathology     Volume:  18     ISSN:  0954-5794     ISO Abbreviation:  Dev. Psychopathol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-26     Completed Date:  2007-03-22     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8910645     Medline TA:  Dev Psychopathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1037-53     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Washington University, St. Louis, MO 63110-1093, USA. gellerb@beckermail.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Aging / genetics,  psychology*
Antidepressive Agents / therapeutic use
Attention Deficit Disorder with Hyperactivity / drug therapy,  psychology*
Bipolar Disorder / drug therapy,  genetics,  psychology*
Central Nervous System Stimulants / therapeutic use
Child
Female
Follow-Up Studies
Humans
Male
Nuclear Family
Outpatients
Phenotype
Puberty
Social Behavior
Grant Support
ID/Acronym/Agency:
R01 MH-53063/MH/NIMH NIH HHS; R01 MH-57451/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Antidepressive Agents; 0/Central Nervous System Stimulants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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