Document Detail

Controlled stress improves oocyte performance - cell preconditioning in assisted reproduction.
MedLine Citation:
PMID:  22827371     Owner:  NLM     Status:  In-Data-Review    
A recently emerged concept utilizing a controlled environmental impact as a treatment for cells and tissues aims to improve neither the in vitro conditions nor the procedures, but the cell itself. Hydrostatic pressure stress emerged as the most controllable and most effective stressor, proving the principle that controlled stress improves cell performance in in vitro procedures, whereas further studies using different stressors (osmotic, oxidative or mechanic stresses) supported the principle. The present summary reviews studies of various stress treatments to treat oocytes of three species (murine, porcine, human) before vitrification, in vitro maturation, enucleation and somatic cell nuclear transfer. Eventually, cleavage and blastocyst rates and - in cases when hydrostatic pressure was used - blastocyst cell number and birth rates as well were significantly improved compared to untreated controls.
C Pribenszky; L Lin; Y Du; E Losonczi; A Dinnyes; G Vajta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Reproduction in domestic animals = Zuchthygiene     Volume:  47 Suppl 4     ISSN:  1439-0531     ISO Abbreviation:  Reprod. Domest. Anim.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9015668     Medline TA:  Reprod Domest Anim     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  197-206     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Verlag GmbH.
Department of Animal Breeding and Genetics, Faculty of Veterinary Science, Szent István University, Budapest, Hungary Beijing Genomics Institute, Shenzhen, China Biotalentum Ltd, Godollo, Hungary Molecular Animal Biotechnology Laboratory, Szent Istvan University, Godollo, Hungary Central Queensland University, Rockhampton, Australia.
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