Document Detail


Controlled release systems of angiogenic growth factors for cardiovascular diseases.
MedLine Citation:
PMID:  17970666     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Worldwide, there is a growing number of patients with myocardial ischemia and limb ischemia associated with the aging population and an increased prevalence of atherosclerotic diseases. Medical therapy, percutaneous angioplasty and surgical revascularization are the present treatments of choice, but such treatments are not feasible for some patients with severe atherosclerosis. Therapeutic angiogenesis using growth factors or progenitor cells has drawn great attention as a favorable alternative treatment for such patients. This review discusses clinical trials using angiogenic growth factors for myocardial ischemia and limb ischemia, and also introduces a novel controlled release system for growth factors using a gelatin hydrogel.
Authors:
Jiro Esaki; Akira Marui; Yasuhiko Tabata; Masashi Komeda
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug delivery     Volume:  4     ISSN:  1742-5247     ISO Abbreviation:  Expert Opin Drug Deliv     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-31     Completed Date:  2008-02-14     Revised Date:  2009-11-17    
Medline Journal Info:
Nlm Unique ID:  101228421     Medline TA:  Expert Opin Drug Deliv     Country:  England    
Other Details:
Languages:  eng     Pagination:  635-49     Citation Subset:  IM    
Affiliation:
Kyoto University Graduate School of Medicine, Department of Cardiovascular Surgery, 54 Kawara, Shogoin, Sakyo, Kyoto 606-8507, Japan.
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inducing Agents / administration & dosage,  therapeutic use*
Animals
Cardiovascular Diseases / therapy*
Delayed-Action Preparations / administration & dosage,  therapeutic use*
Gene Therapy / methods
Humans
Intercellular Signaling Peptides and Proteins / administration & dosage,  therapeutic use*
Myocardial Ischemia / therapy
Myocytes, Cardiac / transplantation
Randomized Controlled Trials as Topic
Chemical
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Delayed-Action Preparations; 0/Intercellular Signaling Peptides and Proteins

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