| Controlled release nifedipine and valsartan combination therapy in patients with essential hypertension: the adalat CR and valsartan cost-effectiveness combination (ADVANCE-combi) study. | |
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MedLine Citation:
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PMID: 17283866 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was designed to compare the clinical efficacy of two calcium channel blocker-based combination therapies with an angiotensin receptor blocker in Japanese patients with essential hypertension. A 16-week, double-blind, parallel-arm, randomized clinical trial was performed to compare the efficacy and safety of the combination therapy of controlled release nifedipine (nifedipine CR) plus valsartan vs. that of amlodipine plus valsartan. The primary endpoint was the target blood pressure achievement rate. Eligible patients were randomly allocated to nifedipine CR-based or amlodipine-based treatment groups. Patients were examined every 4 weeks to determine whether the blood pressure had reached the target level. When the target level was not achieved, the drug regimen was changed; when the target blood pressure was achieved, the same study medication was continued. A total of 505 patients were enrolled in the study (nifedipine CR group: 245 cases; amlodipine group: 260 cases). After 16 weeks of treatment, blood pressure was significantly reduced in both groups, but to a larger extent in the nifedipine CR group than in the amlodipine group (p < 0.01). The target blood pressure achievement rate was also significantly higher in the nifedipine CR group (p < 0.001). There was no significant difference in the incidence of drug-related adverse events between the groups. These results indicate that the nifedipine CR-based combination therapy was superior to the amlodipine-based therapy for decreasing blood pressure and achieving the target blood pressure in patients with essential hypertension. |
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Authors:
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Ikuo Saito; Takao Saruta; |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 29 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-02-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 789-96 Citation Subset: IM |
Affiliation:
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Health Center, Keio University, Yokohama, Japan. saito@hc.cc.keio.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antihypertensive Agents / administration & dosage*, adverse effects, economics Blood Pressure / drug effects Calcium Channel Blockers / administration & dosage*, adverse effects, economics Cost-Benefit Analysis Delayed-Action Preparations Drug Costs Drug Therapy, Combination Female Heart Rate / drug effects Humans Hypertension / drug therapy*, economics Male Middle Aged Nifedipine / administration & dosage*, adverse effects, economics Tetrazoles / administration & dosage*, adverse effects, economics Treatment Outcome Valine / administration & dosage, adverse effects, analogs & derivatives*, economics |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Delayed-Action Preparations; 0/Tetrazoles; 137862-53-4/valsartan; 21829-25-4/Nifedipine; 7004-03-7/Valine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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