Document Detail

Controlled release nifedipine and valsartan combination therapy in patients with essential hypertension: the adalat CR and valsartan cost-effectiveness combination (ADVANCE-combi) study.
MedLine Citation:
PMID:  17283866     Owner:  NLM     Status:  MEDLINE    
This study was designed to compare the clinical efficacy of two calcium channel blocker-based combination therapies with an angiotensin receptor blocker in Japanese patients with essential hypertension. A 16-week, double-blind, parallel-arm, randomized clinical trial was performed to compare the efficacy and safety of the combination therapy of controlled release nifedipine (nifedipine CR) plus valsartan vs. that of amlodipine plus valsartan. The primary endpoint was the target blood pressure achievement rate. Eligible patients were randomly allocated to nifedipine CR-based or amlodipine-based treatment groups. Patients were examined every 4 weeks to determine whether the blood pressure had reached the target level. When the target level was not achieved, the drug regimen was changed; when the target blood pressure was achieved, the same study medication was continued. A total of 505 patients were enrolled in the study (nifedipine CR group: 245 cases; amlodipine group: 260 cases). After 16 weeks of treatment, blood pressure was significantly reduced in both groups, but to a larger extent in the nifedipine CR group than in the amlodipine group (p < 0.01). The target blood pressure achievement rate was also significantly higher in the nifedipine CR group (p < 0.001). There was no significant difference in the incidence of drug-related adverse events between the groups. These results indicate that the nifedipine CR-based combination therapy was superior to the amlodipine-based therapy for decreasing blood pressure and achieving the target blood pressure in patients with essential hypertension.
Ikuo Saito; Takao Saruta;
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  29     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-02-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  789-96     Citation Subset:  IM    
Health Center, Keio University, Yokohama, Japan.
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MeSH Terms
Antihypertensive Agents / administration & dosage*,  adverse effects,  economics
Blood Pressure / drug effects
Calcium Channel Blockers / administration & dosage*,  adverse effects,  economics
Cost-Benefit Analysis
Delayed-Action Preparations
Drug Costs
Drug Therapy, Combination
Heart Rate / drug effects
Hypertension / drug therapy*,  economics
Middle Aged
Nifedipine / administration & dosage*,  adverse effects,  economics
Tetrazoles / administration & dosage*,  adverse effects,  economics
Treatment Outcome
Valine / administration & dosage,  adverse effects,  analogs & derivatives*,  economics
Reg. No./Substance:
0/Antihypertensive Agents; 0/Calcium Channel Blockers; 0/Delayed-Action Preparations; 0/Tetrazoles; 137862-53-4/valsartan; 21829-25-4/Nifedipine; 7004-03-7/Valine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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