| Controlled-release isosorbide dinitrate pellets. Part II: In vivo studies. | |
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MedLine Citation:
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PMID: 8308716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Isosorbide dinitrate (ISDN) capsules containing 20.0 and 40.0 mg of the drug (reported earlier in Part I of this series) were evaluated in vivo in eight healthy volunteers in a double-blind study with marketed sustained-release preparations containing 20.0 and 40.0 mg of ISDN. The results were normalized by administering placebo and four conventional ISDN tablets, each containing 5.0 mg of ISDN, to the same group of volunteers in a separate study. The blood pressure of the volunteers was monitored for 8 h. The results indicate that the capsules prepared in the laboratory with the new formulation gave controlled release when compared with the respective marketed SR product. |
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Authors:
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J K Lalla; S U Bhat; D M Girappanavar |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of pharmaceutical sciences Volume: 82 ISSN: 0022-3549 ISO Abbreviation: J Pharm Sci Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-16 Completed Date: 1994-03-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985195R Medline TA: J Pharm Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1292-5 Citation Subset: IM |
Affiliation:
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Department of Pharmaceutics, Principal K. M. Kundnani College of Pharmacy, Bombay, India. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Chemistry, Pharmaceutical Delayed-Action Preparations Double-Blind Method Heart Rate / drug effects Humans Isosorbide Dinitrate / administration & dosage*, pharmacology Male |
| Chemical | |
Reg. No./Substance:
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0/Delayed-Action Preparations; 87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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