Document Detail

Controlled-release drug delivery systems in cardiovascular medicine.
MedLine Citation:
PMID:  7832110     Owner:  NLM     Status:  MEDLINE    
Controlled-release drug delivery technology has had a significant effect on the pharmacotherapy of cardiovascular diseases. Oral and transcutaneous controlled-release systems allow relatively short-acting drugs to be administered once or twice daily with comparable therapeutic efficacy and fewer adverse reactions compared with standard formulations. They can provide decreased fluctuations in drug concentrations in plasma while possibly reducing the total amount of drug necessary for a clinical response. Techniques include the diffusion, bioerosion or degradation, and generation of osmotic pressure in orally active and transcutaneous drug delivery systems. Calcium-channel blocking agents, nitrates, beta-blocking agents, antiarrhythmic agents, clonidine, and nicotinic acid can be administered by these techniques, which have greatly influenced the application of these drugs in clinical practice.
B Katz; A Rosenberg; W H Frishman
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American heart journal     Volume:  129     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-02-22     Completed Date:  1995-02-22     Revised Date:  2006-02-27    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  359-68     Citation Subset:  AIM; IM    
Department of Medicine, Boston University Medical Center, Mass.
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MeSH Terms
Administration, Cutaneous
Administration, Oral
Cardiovascular Agents / administration & dosage*
Drug Delivery Systems* / methods
Reg. No./Substance:
0/Cardiovascular Agents

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