Document Detail


Controlled release of 5-aminosalicylic acid (5-ASA) from new biodegradable polyurethanes.
MedLine Citation:
PMID:  20428041     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid) (ABHB), 5-[4-(hydroxyphenyl)azo] salicylic acid (HPAS), and 5-[1-hydroxynaphthyl)azo] salicylic acid (HNAS) with hexamethylenediisocyanate (HDI). All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and DSC analysis. All the synthesized azo polymers showed good thermal stability and the onset decomposition temperature of all these polymers was found to be above 195 degrees C under nitrogen atmosphere. The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 1.5) was investigated at body temperature (37 degrees C). The release rate of 5-ASA increased with increasing pH (i.e., 7.8 > 1.5).
Authors:
El-Refaie Kenawy; Salem S Al-Deyab; Mohamed H El-Newehy
Publication Detail:
Type:  Journal Article     Date:  2010-03-30
Journal Detail:
Title:  Molecules (Basel, Switzerland)     Volume:  15     ISSN:  1420-3049     ISO Abbreviation:  Molecules     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-29     Completed Date:  2010-07-30     Revised Date:  2010-12-15    
Medline Journal Info:
Nlm Unique ID:  100964009     Medline TA:  Molecules     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  2257-68     Citation Subset:  IM    
Affiliation:
Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. ekenawy@ksu.edu.sa
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / chemistry,  pharmacokinetics*
Delayed-Action Preparations / chemistry,  pharmacokinetics
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Mesalamine / chemistry,  pharmacokinetics*
Polyurethanes / chemistry*
Spectroscopy, Fourier Transform Infrared
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Delayed-Action Preparations; 0/Polyurethanes; 89-57-6/Mesalamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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