| Controlled low-flow reperfusion after warm brain ischemia reduces reperfusion injury in canine model. | |
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MedLine Citation:
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PMID: 20421252 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Acute occlusion of the carotid artery caused by acute type A aortic dissection (AAD) induces on-going warm brain ischemia. The purpose of this study was to elucidate the hypothesis that low-flow reperfusion could mitigate reperfusion injury after warm ischemic damage to the brain. METHODS: Experiments were performed using a canine global brain ischemia model, with 15 minutes of ischemia followed by 3 hours reperfusion, which was established by a simple brain reperfusion circuit with a roller pump. The right common carotid artery (RCCA) flow ratio was determined as the mean RCCA flow during reperfusion divided by the mean RCCA flow during pre-ischemia. Animals were divided into two groups according to the RCCA flow ratio; low RCCA flow ratio of 0.3 to 0.6 (Group L, n=5) and control RCCA flow ratio of 1.0 to 1.4 (Group C, n=5). At the 3-hour reperfusion time point, physiological and histopathological assessments were performed in both groups. RESULTS: Electroencephalographic activity recovered in four of five animals (80%) animals in Group L, whereas no recovery (0%) in activity was observed in Group C. Brain water content in Group L animals was significantly less than that in Group C. Apoptosis, number of perivascular edematous regions and NFkappaB expression were apparently suppressed in Group L compared with Group C. There were significant positive correlations of RCCA flow with brain water content, apoptosis and number of perivascular edematous regions. CONCLUSIONS: Controlled low-flow reperfusion mitigated reperfusion-induced brain edema and apoptosis, leading to rescue of brain function in the canine model. |
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Authors:
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Hiroshi Munakata; Kenji Okada; Tomomi Hasegawa; Yutaka Hino; Hiroya Kano; Masamichi Matsumori; Yutaka Okita |
Publication Detail:
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Type: Journal Article Date: 2010-04-26 |
Journal Detail:
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Title: Perfusion Volume: 25 ISSN: 1477-111X ISO Abbreviation: Perfusion Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8700166 Medline TA: Perfusion Country: England |
Other Details:
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Languages: eng Pagination: 159-68 Citation Subset: IM |
Affiliation:
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Division of Cardiovascular Surgery, Department of Surgery Kobe University Graduate School of Medicine, Kobe, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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