Document Detail

Controlled inpatient study of tienilic acid in treatment of gout and hypertension.
MedLine Citation:
PMID:  7436563     Owner:  NLM     Status:  MEDLINE    
Under inpatient controlled conditions 4 patients with gout and hypertension were treated with varying doses of tienilic acid, a new uricosuric diuretic. Plasma urate levels were reduced by an average of 50% in association with significantly increased urinary urate excretion. A twice-daily regimen was considerably more effective than a single morning dosage in reduction of plasma urate, though both regimens were equally effective in antihypertensive potency. The single daily regimen produced greater diurnal fluctuations in plasma urate and was more frequently associated with the development of acute gout attacks.
J A Reardon; J T Scott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  39     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-72     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Drug Administration Schedule
Glycolates / therapeutic use*
Gout / complications,  drug therapy*
Hypertension / complications,  drug therapy*
Ticrynafen / administration & dosage,  therapeutic use*
Uric Acid / metabolism
Water-Electrolyte Balance
Reg. No./Substance:
0/Glycolates; 40180-04-9/Ticrynafen; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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