Document Detail

Controlled expansion of a molecular cavity in a steroid host compound.
MedLine Citation:
PMID:  11457222     Owner:  NLM     Status:  MEDLINE    
Expansion of a molecular cavity is described by using elongation of the side chain of a bile acid host compound. Bishomocholic acid (2), which has a side chain that is longer by two methylene unit than cholic acid (1), includes many organic substances at 1:1 host:guest ratios. X-ray crystallographic studies revealed that 2 has two types of open host frameworks: a bilayer type and a crossing type. Both of them are isostructural to those of 1, indicating that they are robust against the elongation of the side chain. In the former type, the increment of the width of the host channel corresponds to that of the length of the molecular structures. Larger aromatic guest components such as 1-methylnaphthalene and 1-tetralone, are included in 2, but not in 1.
K Sada; M Sugahara; K Kato; M Miyata
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  123     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4386-92     Citation Subset:  IM    
Department of Material and Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
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MeSH Terms
Bile Acids and Salts / chemistry*
Cholic Acid / chemistry*
Cholic Acids
Crystallography, X-Ray
Models, Molecular
Spectrophotometry, Infrared
Steroids / chemistry*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Cholic Acids; 0/Steroids; 0/bishomocholic acid; 81-25-4/Cholic Acid

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