| Controlled expansion of a molecular cavity in a steroid host compound. | |
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MedLine Citation:
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PMID: 11457222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Expansion of a molecular cavity is described by using elongation of the side chain of a bile acid host compound. Bishomocholic acid (2), which has a side chain that is longer by two methylene unit than cholic acid (1), includes many organic substances at 1:1 host:guest ratios. X-ray crystallographic studies revealed that 2 has two types of open host frameworks: a bilayer type and a crossing type. Both of them are isostructural to those of 1, indicating that they are robust against the elongation of the side chain. In the former type, the increment of the width of the host channel corresponds to that of the length of the molecular structures. Larger aromatic guest components such as 1-methylnaphthalene and 1-tetralone, are included in 2, but not in 1. |
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Authors:
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K Sada; M Sugahara; K Kato; M Miyata |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 123 ISSN: 0002-7863 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-07-17 Completed Date: 2001-09-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 4386-92 Citation Subset: IM |
Affiliation:
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Department of Material and Life Science, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. sadakazu@ap.chem.eng.osaka-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bile Acids and Salts
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chemistry* Cholic Acid / chemistry* Cholic Acids Crystallography, X-Ray Models, Molecular Spectrophotometry, Infrared Steroids / chemistry* Thermogravimetry |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Cholic Acids; 0/Steroids; 0/bishomocholic acid; 81-25-4/Cholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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