Document Detail

Controlled dissolution from wax-coated aerosol particles in canine lungs.
MedLine Citation:
PMID:  9475885     Owner:  NLM     Status:  MEDLINE    
Treatment of pulmonary and systemic diseases may be improved and toxicity reduced by pulmonary deposition of drug-containing aerosols exhibiting delayed dissolution. Aqueous disodium fluorescein and pentamidine aerosols were dried, concentrated, and condensation coated with paraffin wax. The apparent mass median aerodynamic diameters of the coated fluorescein particles were 2.8-4.0 microns. Wax-to-fluorescein ratios were 0.38-1.05. The dissolution half times determined using a single-pass flow system were 1.5 min for uncoated fluorescein and 0.8 min for uncoated pentamidine. These increased over threefold when the aerosols were coated with paraffin wax to maxima of 5.3 and 2.6 min, respectively. Wax-coated aerosols generated from fluorescein mixed with 99mTc-labeled iron oxide colloid delivered to the canine lungs demonstrated a 3.4-fold increase in the absorption half time of disodium fluorescein compared with uncoated fluorescein (11.2 vs. 38.4 min). The absence of changes in pulmonary function on inhalation of these wax-coated aerosols, together with a high drug load and delayed release, establishes a foundation for future therapeutic applications.
R S Pillai; D B Yeates; I F Miller; A J Hickey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  84     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-03-24     Completed Date:  1998-03-24     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  717-25     Citation Subset:  IM; X    
Department of Chemical Engineering, University of Illinois at Chicago 60612, USA.
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MeSH Terms
Delayed-Action Preparations
Drug Delivery Systems*
Fluorescein / administration & dosage,  chemistry,  pharmacokinetics
Lung / drug effects*
Pentamidine / administration & dosage,  chemistry,  pharmacokinetics
Pharmaceutic Aids*
Respiratory Function Tests
Reg. No./Substance:
0/Aerosols; 0/Delayed-Action Preparations; 0/Pharmaceutic Aids; 100-33-4/Pentamidine; 2321-07-5/Fluorescein; 8002-74-2/Paraffin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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